| 000 | 02636cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032316.0 | ||
| 008 | 190615s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.28.Ph.D.2018.Sa.E | ||
| 100 | 0 | _aSara Ibrahim Falah | |
| 245 | 1 | 0 |
_aEvaluating galectin-3 (LGALS3) +191 gene variant and serum galectin-3 levels in Egyptian children with familial mediterranean fever / _cSara Ibrahim Falah ; Supervised Samia Salah Eldeen Mahmoud , Huda Marzouk Mohamed , Yomna Mohamed Farag |
| 246 | 1 | 5 | _aومستوي الجلاكتين-3 بالدم في الاطفال المصريين المصابين بحمي البحر المتوسط (LGALS3) تقييم التحور الجيني 191+ لجين الجلاكتين 3 |
| 260 |
_aCairo : _bSara Ibrahim Falah , _c2018 |
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| 300 |
_a131 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aBackground:The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Galectin-3 is a Ý-galactoside-binding lectin, which regulate cell-cell and extracellular interactions during self /non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis.It plays a significant role in the inflammatory response, the immune response and tissue fibrosis. The aim of the study isto evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of Albumin / Creatinine Ratio (ACR) | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aFMF | |
| 653 | 4 | _aGalectin-3 | |
| 653 | 4 | _aProteinuria | |
| 700 | 0 |
_aHuda Marzouk Mohamed , _eSupervisor |
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| 700 | 0 |
_aSamia Salah Eldeen Mahmoud , _eSupervisor |
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| 700 | 0 |
_aYomna Mohamed Farag , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72451 _d72451 |
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