| 000 | 02601cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032321.0 | ||
| 008 | 190702s2019 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2019.Di.E | ||
| 100 | 0 | _aDina Mahmoud Lotfy Shaaban | |
| 245 | 1 | 0 |
_aEffect of certain antiepileptic drug(s) with low dose whole body gamma irradiation in modulating pentylenetetrazole-induced convulsions in rats / _cDina Mahmoud Lotfy Shaaban ; Supervised Sanaa A. Kenawy , Seham H. M. Hassan , Marwa M. Safar |
| 246 | 1 | 5 | _aتاثير احد الادوية المضادة للصرع او اكثر مع جرعة صغيرة من تعرض الجسم الكلى للاشعاع الجامى للحد من التشنجات المحدثه بالبنتيلين تيترازول في الجرذان |
| 260 |
_aCairo : _bDina Mahmoud Lotfy Shaaban , _c2019 |
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| 300 |
_a118 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aThe present work was constructed to study the potential therapeutic effect of low dose gamma irradiation alone or combined with valproic acid or topiramate as antiepileptic drugs on an experimental model of acute convulsions induced by pentylenetetrazole in rats. Rats were classified into two sets each one consists of 5 groups. Set I includes groups related to valproic acid alone or combined with low dose whole body gamma irradiation. Set II includes groups related to topiramate alone or combined with low dose whole body gamma irradiation. After pentylenetetrazole injection, Racine{u2019} score, latency and duration of convulsions were observed for 30 min. Moreover, the brain hippocampi contents of biogenic amines (glutamate and GABA) as well as AKT/m-TOR signalling pathway assessment [protein kinase B (AKT), mammalian target of rapamycin (m-TOR), protein S6], caspase 3 relative gene expression was assessed, oxidative stress biomarkers ( MDA, GSH and NO) were examined. Brain hippocampi were also used for histopathological examination | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aLow dose whole body gamma irradiation | |
| 653 | 4 | _aTopiramate | |
| 653 | 4 | _aValproic acid | |
| 700 | 0 |
_aMarwa M. Safar , _eSupervisor |
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| 700 | 0 |
_aSanaa A. Kenawy , _eSupervisor |
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| 700 | 0 |
_aSeham H.M. Hassan , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAsmaa _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72618 _d72618 |
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