| 000 | 023630000a22003610004500 | ||
|---|---|---|---|
| 003 | EG-GICUC | ||
| 005 | 20250223032321.0 | ||
| 008 | 070317s2006 ua a f m 000 0 eng d | ||
| 040 |
_aEG-GICUC _beng _cEG-GICUC |
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| 041 | 0 | _aEng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.07.M.Sc.2006.Ma.R | ||
| 100 | 0 | _aManal Farouk Ahmed Abdelhafiz | |
| 245 | 1 | 0 |
_aRole and significance of DNA methylation in normal and abnormal hematopoiesis / _cManal Farouk Ahmed Abdelhafiz ; Supervised Aisha Mostafa Abdelrahaman , Hoda Mohamed Abdelghani |
| 246 | 1 | 5 | _aدور و قيمة مثيلة الحمض النووى الديؤكسى ريبوزى فى تكوين الدم الطبيعى و الغير طبيعى |
| 260 |
_aCairo : _bManal Farouk Ahmed Abdelhafiz , _c2006 |
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| 300 |
_a160P : _bill ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Clinical and Chemical Pathology | ||
| 520 | _aData suggested that cancer appears to be a process that is fuelled both by genetic alterations and by epigenetic mechanisms Epigenetics refer to the study of changes in gene expression that can be mitotically inherited , but is not associated with the changes in the coding sequence of the affected genes The DNA methylation in the promoter regions is a powerful epigenetic mechanism for the suppression of gene activity Hypomethylation and hypermethylation are the two kinds of methylation defect that is observed in a wide variety of malignancies Hypomethylation is common in solid tumors such as metastatic hepatocellular cancer , in cervical cancer , prostate tumors , and also in hematological malignancies such as B - cell chronic lymphocytic leukemia A large number of genes involving fundamental cellular pathways may be affected by aberrant CpG island methylation in association with transcriptional silencing in virtually all tumor types | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCpG islands | |
| 653 | 4 | _aDNA methylation | |
| 653 | 4 | _aEpigenetics in hematological malignancies | |
| 653 | 4 | _aHypermethylation | |
| 653 | 4 | _aHypomethylation | |
| 700 | 0 |
_aAisha Mostafa Abdelrahaman , _eSupervisor |
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| 700 | 0 |
_aHoda Mohamed Abdelghani , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _ecataloger |
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| 905 |
_aMustafa _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72622 _d72622 |
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