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| 003 | EG-GiCUC | ||
| 008 | 190716s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.21.M.Sc.2019.No.R | ||
| 100 | 0 | _aNoura Elhusseiny Bauomy Mohamed | |
| 245 | 1 | 0 |
_aRole of syndecan-1 in modulating the interaction between monocytes and breast cancer stem cells / _cNoura Elhusseiny Bauomy Mohamed ; Supervised Mona Mostafa Mohamed , Noha Ahmed Mahana , Sherif Abdelaziz Ibrahim |
| 246 | 1 | 5 | _aدور السينديكان-١ فى تعديل التفاعل بين الخلايا احادية النواة و الخلايا الجذعية لسرطان الثدى |
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_aCairo : _bNoura Elhusseiny Bauomy Mohamed , _c2019 |
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_a81 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology | ||
| 520 | _aInflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is characterized by a high infiltration of CD14+ monocytes. A growing body of evidence indicates that tumor-associated macrophages (TAMs) are classified into two major phenotypes, tumor inhibiting M1 and tumor promoting M2. The transmembrane heparan sulfate proteoglycan Syndecan-1 (Sdc-1) expression is induced in a variety of cell types during development and tumor progression and plays an essential role in regulation, recruitment and activation of monocytes in tumor microenvironment. We have recently shown that Sdc-1 is overexpressed in tumor tissue samples of IBC vs non-IBC. However, the role of Syndecan-1 in mediating macrophage polarization is still poorly studied. In the present study, we have employed siRNA approach to silence Syndecan-1 expression in the human breast cancer cell lines MDA-MB-231 (non-IBC) and SUM- 149 (IBC) cells | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aInflammatory breast cancer | |
| 653 | 4 | _aSyndecan-1 | |
| 653 | 4 | _aTmor-associated macrophages and Monocytes | |
| 700 | 0 |
_aMona Mostafa Mohamed , _eSupervisor |
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| 700 | 0 |
_aNoha Ahmed Mahana , _eSupervisor |
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| 700 | 0 |
_aSherif Abdelaziz Ibrahim , _eSupervisor |
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_aShimaa _eCataloger |
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