| 000 | 02759cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032330.0 | ||
| 008 | 190718s2019 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2019.Ma.P | ||
| 100 | 0 | _aMarwa Rabie Khalil Saad | |
| 245 | 1 | 0 |
_aPharmacological study of the effect of some hepatoprotective substances on certain drug-induced hepatotoxic aspects / _cMarwa Rabie Khalil Saad ; Supervised Helmy Moawad Sayed Ahmed , Hala Mahmoud Fawzy , Dalia Moustafa Eltanbouly |
| 246 | 1 | 5 | _aدراسة دوائية لتأثير بعض المواد الواقية للكبد ضد الجوانب السامة المستحدثة ببعض الأدوية |
| 260 |
_aCairo : _bMarwa Rabie Khalil Saad , _c2019 |
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| 300 |
_a150 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology ` | ||
| 520 | _aParacetamol is an extensively used analgesic and antipyretic drug. Overdose of paracetamol, however, is one of the prevailing causes of liver failure worldwide. The present investigation aimed at estimating the hepatoprotective activity of chicory and morus alba leaf extract against paracetamol-induced liver damage in rats, using silymarin as a reference standard. Both extracts (200 and 400 mg/kg, p.o.) were administered for four weeks while silymarin was administered for one week. One hour after the last dose of the tested agents, hepatotoxicity was induced by paracetamol (2 g/kg), orally administered to fasting rats in a single dose. Both doses of chicory and morus alba extracts significantly suppressed liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) activities and total bilirubin level as well as liver lesions evoked by paracetamol overdose. Concomitantly, chicory and morus alba extracts improved the hepatic oxidative status as manifested by elevation of liver nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant enzymes as glutamate cysteine ligase and hemeoxygenase-1 contents as well as glutathione reductase activity. They also raised liver glutathione redox ratio (Reduced glutathione/Oxidized glutathione) and repressed liver lipoperoxidation | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHepatotoxicity | |
| 653 | 4 | _aNrf2 | |
| 653 | 4 | _aParacetamol | |
| 700 | 0 |
_aDalia Moustafa Eltanbouly , _eSupervisor |
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| 700 | 0 |
_aHala Mahmoud Fawzy , _eSupervisor |
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| 700 | 0 |
_aHelmy Moawad Sayed Ahmed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAsmaa _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c72953 _d72953 |
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