000			02914cam a2200349 a 4500
003			EG-GiCUC
005			20250223032332.0
008			190722s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.09.M.Sc.2018.Em.P
100	0		_aEman Shafik Zaki
245	1	4	_aThe Possible protective effect of bone marrow transplantation with some natural products against cytogenetical aberrations and liver cell damage induced by carbon tetrachloride / _cEman Shafik Zaki ; Supervised Ezz Eldin S. Eldenshary , Mohammed F. Elyamany , Muhammed Abdullatif saad
246	1	5	_aدراسة التأثير الوقائى المحتمل لزراعة نخاع العظم مع المنتجات الطبيعية ضد التشوهات الوراثية الخلوية وتدمير الخلايا الكبدية المستحدث برباعى كلوريد الكربون
260			_aCairo : _bEman Shafik Zaki , _c2018
300			_a168 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520			_aLiver fibrosis is a major health problem that can lead to liver cirrhosis and hepatic carcinoma. This study investigates the hepatoprotective effect of bone marrow mononuclear cells (BM-MNCs) transplantation, N-acetylcysteine (NAC) and Ü-lipoic acid (ALA) against hepatic toxicity and cytogenetical aberrations experimentally induced by carbon tetrachloride (CCl₄ in rats. Rats are administrated CCl4 (1mg/kg, i.p.) twice/week for 8 weeks showed elevation of liver enzymes ALT, AST in serum, liver tissue TNF-Ü, IL-6 inflammatory cytokines, while a reduction of albumin serum level and IL-10 anti-inflammatory cytokines, oxidative stress biomarkers as SOD, CAT, GPx, TAC liver tissue content accompanied by elevation of MDA liver content. In addition to cytogenetical aberration assessment via micronucleated polychromatic erythrocytes (MnPCEs) count, percent (%) of DNA damaged cells. Administration of BM-MNCs (1{u00D7}10⁶ in 0.1ml PBS, i.v.), NAC (300 mg/kg, p.o), ALA (100 mg/kg, p.o) alone and their combinations (BM-MNCs with NAC and BM-MNCs with ALA) decreased tissue content of TNF-Ü, IL-6, MDA, percentage of DNA damaged cells and MnPCEs and increase others as GPx, CAT, SOD, TAC and IL-10. Also, these agents produced marked reduction of liver enzymes ALT, AST, serum albumin
530			_aIssued also as CD
653		4	_aHepatoprotective agent
653		4	_aHepatotoxicity
653		4	_aOxidative stress
700	0		_aEzz Eldin S. Eldenshary , _eSupervisor
700	0		_aMohammed F. Elyamany , _eSupervisor
700	0		_aMuhammed Abdullatif saad , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c73019 _d73019