000 02344cam a2200349 a 4500
003 EG-GiCUC
005 20250223032333.0
008 190722s2018 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.03.M.Sc.2019.Ya.L
100 0 _aYasmin Hesham Ali Elwan
245 1 0 _aLevel of autophagy in lichen planus role of endoplasmic reticulum stress proteins /
_cYasmin Hesham Ali Elwan ; Supervised Salwa Fayez , Rania Mounir Abdelhady , Taha Abdelrazik Darweesh
246 1 5 _aمستوي الالتهام الذاتي في مرض الحزازالمسطح: دور بروتينات الاجهاد الخاصة بالشبكة الاندوبلازمية
260 _aCairo :
_bYasmin Hesham Ali Elwan ,
_c2019
300 _a137 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry
520 _aLichen Planus (LP) is a dermatological disease affecting skin &{u2044}or mucous membranes. It is a common T cell-mediated chronic in{uFB02}ammatory disease, which has been hypothesized that T cell autophagy is involved in the immunopathogenesis of oral lichen planus (OLP). Beclin-1 plays an important role in a critical step of the autophagic process. Heat shock proteins (HSP) being the molecular chaperones, their transcription is activated in response to various stressors and plays an important role in Endoplasmic reticulum stress (ER stress) pathway. HSPs probably represent the antigenic proteins that may potentially be involved in both the initiation and the persistence of the autoimmune lymphocytic response of lichen planus. GRP78( glucose regulated potein 78) is one of the HSP; ATF6 (activated transcription factor6) is one of ER stress pathway sensors. This study aims at detecting the level of autophagy and ER stress proteins in lichen planus
530 _aIssued also as CD
653 4 _aATF6
653 4 _aGRP78
653 4 _aLichen planus
700 0 _aRania Mounir Abdelhady ,
_eSupervisor
700 0 _aSalwa Fayez ,
_eSupervisor
700 0 _aTaha Abdelrazik Darweesh ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c73030
_d73030