| 000 | 02589cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032336.0 | ||
| 008 | 190728s2019 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.03.M.Sc.2019.Ma.P | ||
| 100 | 0 | _aMaha Gomaa Sayed Ahmed | |
| 245 | 1 | 0 |
_aPossible association between heme oxygenase-1 (HO-1) polymorphism and level of reactive oxygen species (ROS), in Egyptian type 2 diabetic patients / _cMaha Gomaa Sayed Ahmed ; Supervised Dina Sabry Abdelfatah , Miriam Safwat Wadie , Randa Fayez Salama |
| 246 | 1 | 5 | _aامكانية الاقتران بين تعدد الشكل الجينى لهيم اوكسيجيناز 1 ومستوى انواع الاكسجين التفاعلية فى المصريين مرضى السكرى النوع الثانى |
| 260 |
_aCairo : _bMaha Gomaa Sayed Ahmed , _c2019 |
||
| 300 |
_a128 P. : _bcharts ; _c25cm |
||
| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry | ||
| 520 | _aDiabetes is a fast-growing health problem in Egypt with a significant impact onmorbidity, mortality, and health care resources. Currently, the prevalence of type-2 diabetes (T2D) in Egypt is around 15.6% of all adults aged 20 to 79. Oxidative stress (OS) has been suggested to be an important mechanism in the development of T2D complications. In the antioxidative system, heme oxygenase-1 (HO-1) acts as a key factor in mechanisms to mitigate oxidative stress because of its potent antiinflammatory, antioxidant, and antiproliferative actions. In addition, impaired HO-1 protein expression/activity may be related to the pathogenic process induced by OS. HO-1 gene promoter polymorphisms modulate its transcription in response to oxidative stress.This study screened for HO-1 polymorphisms and investigated the association between HO-1 polymorphisms and ROS levels in the serumin Egyptian diabetic population in comparison to control group. This study includes 3 groups: one hundred healthy subjects (control group), one hundred type {u2160} diabetic (T1D) patients and one hundred and fourteen T2D patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHO-1 | |
| 653 | 4 | _aT1D | |
| 653 | 4 | _aT2D | |
| 700 | 0 |
_aDina Sabry Abdelfatah , _eSupervisor |
|
| 700 | 0 |
_aMiriam Safwat Wadie , _eSupervisor |
|
| 700 | 0 |
_aRanda Fayez Salama , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c73130 _d73130 |
||