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| 003 | EG-GiCUC | ||
| 005 | 20250223032344.0 | ||
| 008 | 190920s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.06.Ph.D.2019.As.S | ||
| 100 | 0 | _aAshraf Osman Abdellatif Mohamed | |
| 245 | 1 | 0 |
_aStudy on the potential antimicrobial activities of Melaleuca spp. plant against skin infecting microbes and detection of their possible mutagenic effect using molecular methods / _cAshraf Osman Abdellatif Mohamed ; Supervised Mohammed A. M. Ramadan , Alaa Eldein M. S. Hosny , Mohamed Abdelaaty M. Rabeh |
| 246 | 1 | 5 | _aدراسة علي الفاعلية المحتملة لنبات الميلالوكا ضد الميكروبات المُعدِية للجلد والكشف عن التأثير المحتمل لإحداث طفرات باستخدام طرق جزيئية |
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_aCairo : _bAshraf Osman Abdellatif Mohamed , _c2019 |
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| 300 |
_a162 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology | ||
| 520 | _aIntroduction: The extracts and oils from Melaleuca spp.leaves (Myrtaceae family) have been traditionally used as a topical therapeutic agent for the treatment of various skin infections. The current study aimed to evaluate the potential antimicrobial activities of the different active components of Melaleuca spp. plant as topical agents against some medically important pathogens related to the common skin infections and detection of their possible mutagenic effect. Methods: The M. alternifolia leaves were subjected to successive fractionation using different solvents with different polarities.The TTOwas extractedfrom plant leaves using steam hydro-distillation andthen subjected to GC/MS analysis to characterize its main components. The aqueous extract fraction was used to synthesize silver nanoparticles (AgNPs) via green nanotechnology. The different extracted fractions, TTO, and AgNPs were evaluated for their antimicrobial activities against representativeskin-infecting pathogen including bacteria, fungi and viruses.Furthermore, theTransmission electron microscope examination was used to characterize the synthesized AgNPs and to visualize the treated microbial cells to figure out the basic changes that may be referred to a certain mode of action.Moreover, the possible mutagenic effect of TTO and AgNPs was investigated against S. typhimurium TA89 and TA100 strains using the Ames test | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aGC/MS | |
| 653 | 4 | _aSilver nanoparticles | |
| 653 | 4 | _aTea tree oil | |
| 700 | 0 |
_aAlaa Eldein M. S. Hosny , _eSupervisor |
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| 700 | 0 |
_aMohamed Abdelaaty M. Rabeh , _eSupervisor |
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| 700 | 0 |
_aMohammed A. M. Ramadan , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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