| 000 | 02450cam a2200337 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032348.0 | ||
| 008 | 190828s2019 ua f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.10.M.Sc.2019.Ah.S | ||
| 100 | 0 | _aAhmed Sabri Abdelmoety Gabr | |
| 245 | 1 | 0 |
_aSynthesis of some New pyrazolo[1,5-a]pyrimidine derivatives with expected biological activity / _cAhmed Sabri Abdelmoety Gabr ; Supervised Hussein Fouad Zohdi , Nadia Hanafy Metwally |
| 246 | 1 | 5 | _a1,5-aتشييد بعض مشتقات البيرازولو يريميدين الجديدة و المتوقع لها نشاط بيولوجى |
| 260 |
_aCairo : _bAhmed Sabri Abdelmoety Gabr , _c2019 |
||
| 300 |
_a100 P. ; _c25cm |
||
| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry | ||
| 520 | _aThe condensation of 2-(cyanomethyl)-7-(thiophen-2-yl)-5-(trifluoromethyl)pyrazolo- [1,5-a]pyrimidine-3-carbonitrile (3) with various aromatic aldehydes afforded crossponding substituted pyrazolo[1,5-a]pyrimidines 5a-j. The reaction of compound 3 with aryl diazonium chlorides in N,N-dimethylformamide furnished arylhydrazo compounds based pyrazolo[1,5-a]pyrimidine derivative. Also, reaction of compound 3 with 4-aryl azosalicylaldehydes afforded polyheterocyclic compounds based pyrazolo[1,5-a]pyrimidine derivative. The treatment of compound 3 with phenyl isothiocyanate, followed by addition of -haloesters or haloketones afforded polyheterocyclic compounds. Moreover, the enamines compound 3 react with each of hydrazine hydrate, guanidine hydrochloride to give the pyrazolo and pyrimidine derivatives. The structures of all the newly synthesized products were established by their elemental analyses, spectral data and possible mechanism has been postulated to account for their formation. The antiviral activity of some selected newly synthesized compounds was investigated | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _a2-(cyanomethyl)-7-(thiophen-2-yl)-5-(trifluoromethyl)pyrazolo- [1,5-a] | |
| 653 | 4 | _aPolyfused heterocyclic compounds | |
| 653 | 4 | _apyrimidine-3-carbonitrile | |
| 700 | 0 |
_aHussein Fouad Zohdi , _eSupervisor |
|
| 700 | 0 |
_aNadia Hanafy Metwally , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aSamia _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c73532 _d73532 |
||