| 000 | 02496cam a2200325 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 008 | 190902s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.07.Ph.D.2019.Ri.A | ||
| 100 | 0 | _aRiham Adel Elshiekh | |
| 245 | 1 | 0 |
_aAssessment of some medicinal plants for treatment of obesity / _cRiham Adel Elshiekh ; Supervised Mohamed S. Hifnawy , Essam A. Abdelsattar , Dalia A. Almahdy |
| 246 | 1 | 5 | _aتقييم بعض النباتات الطبية لعلاج السمنة |
| 260 |
_aCairo : _bRiham Adel Elshiekh , _c2019 |
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| 300 |
_a195 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy | ||
| 520 | _aThe total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants. An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz: sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LC{u2013}MS analysis for its content of stemmoside C | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aSolenostemma argel | |
| 653 | 4 | _aÜ-Amylase | |
| 653 | 4 | _aÜ-Glucosidase | |
| 700 | 0 |
_aDalia A. Almahdy , _eSupervisor |
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| 700 | 0 |
_aEssam A. Abdelsattar , _eSupervisor |
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| 700 | 0 |
_aMohamed S. Hifnawy , _eSupervisor |
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_aAsmaa _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c73591 _d73591 |
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