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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.28.Ph.D.2019.Ha.T
100 0 _aHanan Tawfik Abdelaziz
245 1 0 _aToll-like receptor 4 gene polymorphisms in Egyptian children with familial mediterranean fever /
_cHanan Tawfik Abdelaziz ; Supervised Samia Salah Eldin Mahmoud , Huda Marzouk Mohamed , Yomna Mohamed Farag
246 1 5 _aالتعدد الشكلى الجينى فى المستقبل شبيه التول 4 عند الأطفال المصريين المصابين بحمى البحر المتوسط
260 _aCairo :
_bHanan Tawfik Abdelaziz ,
_c2019
300 _a143 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aObjective: Familial Mediterranean Fever (FMF) is an autosomal recessive, disorder affecting people in the region of Mediterranean Sea. MEFV gene that encodes the pyrin protein has an influences on the inflammatory response. Toll like receptors (TLR) are a family of pattern recognition receptor that recognize pathogenic microbes and activate antimicrobial defense mechanisms. Toll like receptor 4 (TLR-4) is concerned with recognition of gram negative organism. The aim of the current study is to evaluate the presence of TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms in association with Egyptian children having FMF, furthermore its effect on disease course and severity. Methods: Seventy Egyptian children diagnosed as having FMF, together with fifty controls, Age and Sex- matched. The TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms were determined by (PCR-RFLP) analysis for all studied patients and control
530 _aIssued also as CD
653 4 _aFamilial Mediterranean fever
653 4 _aToll like receptor 4
653 4 _aToll like receptors
700 0 _aHuda Marzouk Mohamed ,
_eSupervisor
700 0 _aSamia Salah Eldin Mahmoud ,
_eSupervisor
700 0 _aYomna Mohamed Farag ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAsmaa
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c73598
_d73598