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| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.19.03.Ph.D.2019.La.P | ||
| 100 | 0 | _aLamiaa Abdelfattah Fathalla Ahmed | |
| 245 | 1 | 0 |
_aPrevalence and prognostic implication Of BCR/ABL fusion gene expression & JAK2 overexpression In Egyptian acute myeloid leukemia patients / _cLamiaa Abdelfattah Fathalla Ahmed ; Supervised Basma Mostafa Mohammed Elgamal , Naglaa Mostafa Hassan Ahmed , Omnia Kamal Elgebaly |
| 246 | 1 | 5 | _aفى مرض سرطان الدم الميلودى الحاد فى المصريين و علاقتهم بالتنبؤ المرضى لديهم JAK2 و زيادة تعبير ال BCR/ABL دراسة نسبة انتشار جين ال |
| 260 |
_aCairo : _bLamiaa Abdelfattah Fathalla Ahmed , _c2019 |
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| 300 |
_a157 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology | ||
| 520 | _aBackground: Acute myeloid leukemia (AML) is a heterogenous disease with multiple established prognostic factors. JAK2 overexpression in AML was confirmed by many authors with an influence on the overall survival. Philadelphia positive AML (Ph+ AML) is a provisional entity in the recent WHO classification where discrimination from acute blastic crisis on top of chronic myeloid leukemia (CML) is still a challenge. Aims: to study JAK2 gene expression pattern in AML patients and its relation with other established prognostic variables and outcome parameters. Also, to determine the prevalence of the BCR-ABL fusion gene in AML cases with determination of the clinical and laboratory criteria of these cases. Methods: Prospective study on 175 AML patients treated at medical and pediatric oncology departments. Jak2 gene expression was evaluated by real time RT-PCR using taqman primer probe assay and BCR/ABL fusion was tested by conventional RT-PCR. All patients received current standard of care treatment for AML at NCI, Cairo University, Egypt | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBCR/ABL | |
| 653 | 4 | _aJAK2 | |
| 653 | 4 | _aPh+ AML | |
| 700 | 0 |
_aBasma Mostafa Mohammed Elgamal , _eSupervisor |
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| 700 | 0 |
_aNaglaa Mostafa Hassan Ahmed , _eSupervisor |
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| 700 | 0 |
_aOmnia Kamal Elgebaly , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aShimaa _eCataloger |
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