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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.04.M.Sc.2019.La.E
100 0 _aLaila Sulaiman Saleh Bashuqair
245 1 0 _aElevated NT-pro BNP plasma level as a marker of acute and sub-acute ventricular affection in breast cancer patients receiving chemotherapy /
_c Laila Sulaiman Saleh Bashuqair ; Supervised Magdy Abdelhamid , Ghada Sayed Mahmoud , Dina Hesham Ahmed Soliman
246 1 5 _aفي البلازما كمؤشر لتأثر البطين الحاد و تحت الحاد في مريضات سرطان الثدي اللاتي يأخدنا علاجا كيميائيا ( NT-pro BNP )ارتفاع هرمون
260 _aCairo :
_bLaila Sulaiman Saleh Bashuqair ,
_c2019
300 _a107 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology
520 _aBackground: Chemotherapeutic agents used for treatment of breast cancer have many side effects, among them is cardiomyopathy. Despite that ejection fraction (EF) is a widely accepted echocardiographic method, yet it fails to detect subtle alterations of LV function. There comes a need for a more sensitive tool for detection of preclinical chemotherapy-induced cardiomyopathy. Purpose: Detection of preclinical LV systolic and/or diastolic dysfunction, using NT-BNP plasma level in breast cancer patients within 6 weeks after the initiation of their chemotherapeutic treatment. Methods: Seventy-four non-metastasizing breast cancer female patients with no cardiovascular risk factors were included. They were assessed right before taking their first chemotherapeutic session and 6 weeks thereafter. Assessment included age, two-dimensional (2D) as well as three-dimensional (3D) echocardiography. Blood samples for NT-BNP plasma level were collected before and 6 weeks after the initiation of chemotherapy. Samples were later analyzed using a Sandwich ELISA technique
530 _aIssued also as CD
653 4 _aBreast cancer
653 4 _aLV dysfunction
653 4 _aNT-BNP plasma level
700 0 _aDina Hesham Ahmed Soliman ,
_eSupervisor
700 0 _aGhada Sayed Mahmoud ,
_eSupervisor
700 0 _aMagdy Abdelhamid ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAsmaa
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c73797
_d73797