000			02848cam a2200325 a 4500
003			EG-GiCUC
008			190928s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.07.Ph.D.2019.Sa.P
100	0		_aSarah Tareq Esmail Ali Sakna
245	1	2	_aA phytochemical and biological study of certain Ziziphus species growing in Egypt / _cSarah Tareq Esmail Ali Sakna ; Supervised Marwan Marwan Shabana , Nabaweya Mostafa Elfiky , Mohammed Ali Farag
246	1	5	_aدراسة فيتوكيميائيه و بيولوجيه لبعض أنواع السدر التى تنمو فى مصر
260			_aCairo : _bSarah Tareq Esmail Ali Sakna , _c2019
300			_a263 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aGenus Ziziphus (Rhamnaceae) is well characterized for its multi benefits aside from its fruit nutritive value, its leaf decoction is a common healthy beverage in many cultures. Albeit, no detailed metabolites characterization is reported for its leaf till now, with most research focused on its fruits. Here we have employed UHPLC/PDA/ESI-MS technique to characterize the secondary metabolites profile of three traditionally used Ziziphus leaf taxa including: Z. spina-christi, Z. mauritiana and Z. jujuba revealing the first full insight onto Ziziphus leaf metabolome. A total of 102 metabolites were characterized including several novel flavonoids and cyclopeptide alkaloids first time to be reported from the genus. Additionally, fragmentation pattern for cyclopeptide alkaloids was proposed via ESI-MS. Principal component analysis (PCA) revealed close metabolite resemblance among Z. spina-christi and Z. mauritiana leaf specimens found enriched in saponins and distinct from that of Z. jujuba in which quercetin-3-O-(2-pentosyl)-rhamnoside was most abundant. In-vitro antioxidant, Ü-glucosidase, COX-1 and tyrosinase inhibitory assays revealed for Z. spina-christi and Z. mauritiana strong effects compared to Z. jujuba and in correlation with their metabolites repertoire supporting their medicinal values. Isolation of 4 triterpenic acids, 1 flavonoid and 1 saponin was achieved from Z. mauritiana Lam. leaf revealed as one of the most active investigated species. Further, antidiabetic effectiveness of Z. mauritiana on streptozocin induced diabetic rats was also investigated
530			_aIssued also as CD
653		4	_aFlavonoids
653		4	_aUHPLC-MS
653		4	_aZiziphus
700	0		_aMarwan Marwan Shabana , _eSupervisor
700	0		_aMohammed Ali Farag , _eSupervisor
700	0		_aNabaweya Mostafa Elfiky , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c74185 _d74185