000			02270cam a2200325 a 4500
003			EG-GiCUC
008			191001s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.04.Ph.D.2019.Is.S
100	0		_aIslam Zaki Abdelazeem Abutaleb
245	1	0	_aSynthesis and biological evaluation of some new nitrogen heterocyclic compounds / _cIslam Zaki Abdelazeem Abutaleb ; Supervised Mohammed Kamal Abdelhameid , Khaled Omar Ahmed Mohamed , Ibrahim Elsayed Mohey Eldeen
246	1	5	_aالتشييد والتقييم البيولوجى لبعض المركبات النيتروجينية الغير متجانسة الجديدة
260			_aCairo : _bIslam Zaki Abdelazeem Abutaleb , _c2019
300			_a183 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
520			_aA new series of diamide, imidazolone, 1,2,4-triazole and 1,2,4-triazinone derivatives have been designed, synthesized starting from N-benzoylglycine derivatives. Structures of the synthesized compounds have been deduced on the basis of their spectroscopic methods and elemental analyses data. The in vitroantitumor activity of the newly synthesized compounds were screenedagainstHepG2 and MCF-7 cell lines. Cell cycle analysis were carried out for some of the prepared compounds and demonstrated cell cycle arrest at G1 or G2/M phases of cell cycle.Additionally, the compounds produced a significant reduction in cellular microtubules for microtubule loss and potently inhibited the binding of [3H]colchicine to tubulin. Finally, some of the prepared compounds were proved to upregulate expression of proteins triggering apoptosis such as p53, Bax and decreased Bcl-2 overexpression as well as increased the expression of effector caspase-3/7.
530			_aIssued also as CD
653		4	_aDiamide
653		4	_aImidazolone
653		4	_aOxazolone
700	0		_aIbrahim Elsayed Mohey Eldeen , _eSupervisor
700	0		_aKhaled Omar Ahmed Mohamed , _eSupervisor
700	0		_aMohammed Kamal Abdelhameid , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c74258 _d74258