000			02878cam a2200349 a 4500
003			EG-GiCUC
005			20250223032411.0
008			191005s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.28.Ph.D.2019.Mo.R
100	0		_aMohamed Ahmed Abdeltawab
245	1	4	_aThe role of mannose binding lectin (MBL2) gene polymorphism in incidence of neonatal sepsis / _cMohamed Ahmed Abdeltawab ; Supervised Ismail Mohamed Bahi Eldin Elhawary , Nouran Fahmy Hussain , Aliaa Adel Ali
246	1	5	_aدراسة دور تعدد الأشكال الجيني لكتين ملزم المانوز فى الاطفال حديثي الولادة المصابين بمرض تسمم الدم
260			_aCairo : _bMohamed Ahmed Abdeltawab , _c2019
300			_a151 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aIntroduction: Mannose-binding lectin (MBL) is a component of innate immunity and is particularly important in neonates, in whom adaptive immunity has not yet completely developed. MBL deficiency and MBL2 gene polymorphisms are associated with an opsonization defect and have been associated with neonatal sepsis. Aim: The aim of this work was to assess the role of serum MBL level as a diagnostic value of neonatal sepsis and to assess the relation of MBL2 gene polymorphism at codon 54 (G/A) in the development of neonatal sepsis. Patients and Methods: A case-control study was conducted with 100 preterm neonates classified into two groups: the septic group included 50 neonates and the non-septic control group included 50 neonates. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype MBL2 gene exon 1 (codon 54 (G/A), rs1800450) SNPs. Enzyme-linked immunosorbent assay (ELISA) was used to measure MBL serum concentrations. Results: Serum MBL was significantly lower in septic neonates than the controls (P<0.0001).The heteromutant (GA) genotype of codon 54 was significantly higher in septic neonates than controls (P=0.033). However, the homomutant (AA) genotype of codon 54 was higher in septic neonates than controls but the difference did not reach statistical significance (P=0.242). The abnormal A allele was significantly higher in septic neonates than controls (P=0.0025)
530			_aIssued also as CD
653		4	_aCodon 54
653		4	_aGene polymorphism
653		4	_aMannose-binding lectin
700	0		_aAliaa Adel Ali , _eSupervisor
700	0		_aIsmail Mohamed Bahi Eldin Elhawary , _eSupervisor
700	0		_aNouran Fahmy Hussain , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c74300 _d74300