000			02957cam a2200325 a 4500
003			EG-GiCUC
008			191009s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2017.Ra.A
100	0		_aRadwa Bakry Mohammad
245	1	0	_aAssociation of pentraxin 3 with atherosclerosis in patients with type 2 diabetes / _cRadwa Bakry Mohammad ; Supervised Nehal Hamdy Elsaid , Naglaa Mohamed Elsayed , Nagwa Abdelghaffar Mohamed
246	1	5	_aارتباط البنتركسين 3 مع تصلب الشرايين فى مرضى البول السكرى من النوع الثانى 2
260			_aCairo : _bRadwa Bakry Mohammad , _c2017
300			_a130 P. : _bcharts , facimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aBackground:Type 2 diabetes mellitus is a major health problem that is rising with time.Type 2 diabetes mellitus lead to several complications including cardiovascular diseases. Cardiovascular disease is a main cause of death globally. Both of inflammatory factors and immune response are involved in atherosclerosis development. Pentraxin is a reactant of acute phase which shares functional and structural homology with CRP. Pentraxin concentration rises after episodes such as acute myocardial infarction.Objective:To evaluate the association between pentraxin 3 and atherosclerosis disease in type 2 diabetes mellitus patients.Patients and Method:This is a case control study that included 3 groups, the first group included patients with type 2 diabetes mellitus and known cardiovascular complication, the second group included type2 diabetes mellitus patients without complications and the third group included healthy individuals. Clinical examination and laboratory investigation were performed for all participants as well as pentraxin 3.Results: By comparing the results of the three groups, there were significant differences between the three groups regarding each of SBP, DBP, FBS, 2Hr PP and HbA1c where P-value {u02C2}0.001 for each, also there were significant differences regarding AST (P=0.02), creatinine (P=0.01), creatinineclearance (P=0.008), pentraxin (P {u02C2}0.001)and carotid intima media thickness (P{u02C2}0.001). In diabetic group with complication, pentraxin was found to change with carotid intima media thickness (Ý=67.466, P{u02C2}0.001).Conclusion: Pentraxin is associated with atherosclerosis in patients with type 2 diabetes mellitus
530			_aIssued also as CD
653		4	_aCardiovascular disease
653		4	_aDM
653		4	_aPentraxin
700	0		_aNaglaa Mohamed Elsayed , _eSupervisor
700	0		_aNagwa Abdelghaffar Mohamed , _eSupervisor
700	0		_aNehal Hamdy Elsaid , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c74354 _d74354