000			02818cam a2200349 a 4500
003			EG-GiCUC
005			20250223032423.0
008			191024s2019 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.19.05.M.Sc.2019.Ho.P
100	0		_aHosam Yusri Mohammed
245	1	0	_aPrognosis of loco-regional wilms{u2019} tumor in pediatric cancer patients, a single-institution experience / _cHosam Yusri Mohammed ; Supervised Wael Zekri Khaled , Sahar Khalil , Elsayed Ashraf
246	1	5	_aنتائج حالات ورم ويلمز المرحلة الأولى و الثانية و الثالثة فى الاطفال : _bتجربة مؤسسة واحدة
260			_aCairo : _bHosam Yusri Mohammed , _c2019
300			_a110 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aBackground: Nephroblastoma (Wilms{u2019} tumor) WT represents about 6 % of all childhood cancers, and it is the most common pediatric renal tumor. The overall survival markedly improved to exceed 90 percent in developed countries, yet some studies from developing counties still have poorer outcomes. Purpose: To assess the clinical outcome and the different prognostic factors that might influence the outcome of pediatric loco-regional WT cases at initial presentation treated at National Cancer Institute (NCI), Cairo University, Egypt. Methods: This is a retrospective study included pediatric loco-regional WT patients presented to NCI, between January 2008 and June 2017. Medical records of all patients were reviewed for clinical features, imaging studies, treatment and outcome. Patients were followed up till December 2018. Results: In 90 eligible patients, median age was 3 years (range 1 month{u2013}9 years). Abdominal mass was the commonest presentation (75.6 %). At the end of the study, EFS and OS was 82.8% and 93.4%. Despite having a similar EFS (83.7 vs. 81.8%), Stage III cases had a significantly lower OS than stage I and II (88.4% vs. 100 % p value 0.024). Eleven cases had unfavorable histology and had a significantly lower EFS and OS than the cases with favorable histology (45.5 and 81.8% vs. 88.2 and 96.1%). If we considered cases with nuclear unrest with the favorable histology group, the difference in EFS wouldn{u2019}t be statistically significant
530			_aIssued also as CD
653		4	_aEgypt
653		4	_aLoco-regional
653		4	_aWilms' tumor
700	0		_aElsayed Ashraf , _eSupervisor
700	0		_aSahar Khalil , _eSupervisor
700	0		_aWael Zekri Khaled , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c74725 _d74725