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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.28.Ph.D.2019.Me.A
100 0 _aMehan Abdalla Mohamed
245 1 0 _aAssessment of cardiac functions and arrhythmia in clinically asymptomatic children with beta-thalassemia major and beta-thalassemia intermedia /
_cMehan Abdalla Mohamed ; Supervised Khaled Mohamed Salama , Rasha Abdelraouf Abdelaziz , Hadeel Mohamed Seif Eldin
246 1 5 _aتقييم وظائف القلب وعدم انتظام ضربات القلب فى الاطفال مرضى انيميا البحر المتوسط الكبرى والوسطى
260 _aCairo :
_bMehan Abdalla Mohamed ,
_c2019
300 _a125 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aBack ground: Heart disease remains the major cause of morbidity and mortality in thalassemic patients. Heart injuries in iron overload cases include dilatation of the atria and ventricles, arrhythmia, pulmonary hypertension, systolic/diastolic dysfunction and finally heart failure. Echocardiographic techniques are non invasive, widely available and can be used to assess cardiac function. Assessment of cardiac iron load can be performed directly using Cardiac Magnetic resonance imaging T2* (CMRIT2*), a sensitive, noninvasive imaging, to correlate the cardiac iron status to echocardiographic and holter {uFB01}ndings. Aim: Assessment of cardiac functions and arrhythmia in children with Ý-Thalassemia Major and Ý-Thalassemia Intermedia and its correlation to CMRIT2* data as an indicator for cardiac iron overload. Methods: In this cross-sectional study, 30 patients with Ý- thalassemia major (TM) and 30 patients with Ý-thalassemia intermedia (TI) underwent full history taking, clinical examination and laboratory tests including (complete blood count, ALT, AST, Bl. urea, s. creatinine and serum ferritin). All patients were evaluated using 24-hour ambulatory electrocardiogram monitoring (Holter) and echocardiography, while only 15 patients with Ý- TM and 15 patients with Ý- TI were evaluated using CMRIT2*
530 _aIssued also as CD
653 4 _aArrhythmia
653 4 _aEchocardiography
653 4 _aThalassemia
700 0 _aHadeel Mohamed Seif Eldin ,
_eSupervisor
700 0 _aKhaled Mohamed Salama ,
_eSupervisor
700 0 _aRasha Abdelraouf Abdelaziz ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAsmaa
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c75138
_d75138