000			02107cam a2200325 a 4500
003			EG-GiCUC
008			191119s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.19.03.Ph.D.2017.Fa.S
100	0		_aFatma Mahmoud Ibraheem
245	1	0	_aSALL4 gene expression in acute myeloid leukemia / _cFatma Mahmoud Ibraheem ; Supervised Ragia Hussein Badawy , Naglaa Moustafa Hassan , Mahmoud Aly Ayoub
246	1	5	_aظهور جين السول فور فى حالات سرطان الدم الميودي الحاد
260			_aCairo : _bFatma Mahmoud Ibraheem , _c2017
300			_a158 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology
520			_aSALL4 gene was aberrantly expressed in many leukemia cell lines and primary leukemia cells of acute myeloid leukemia (AML). The aim of this study was to investigate the expression level of the gene and its clinical significance in patients with acute myeloid leukemia (AML). Quantitative real-time PCR (qrt-PCR) was performed to detect the expression level of SALL4 mRNA in the bone marrow or peripheral blood samples from 52 AML and 10 control samples. The results indicated that the expression level of SALL4 in AML (median: 2.0 RQ) was obviously higher than that in controls (media: 1 RQ) with p value: 0.001. There was no statistically significant difference between cases and control in SALL4 gene expression with the age, sex, WBC count, Hb concentration, platelet count, chromosomal abnormalities of AML patients, FAB and WHO classification (P > 0.05)
530			_aIssued also as CD
653		4	_aAcute myeloid leukemia (AML)
653		4	_aQuantitative real-time PCR (qrt-PCR)
653		4	_aSALL4
700	0		_aMahmoud Aly Ayoub , _eSupervisor
700	0		_aNaglaa Moustafa Hassan , _eSupervisor
700	0		_aRagia Hussein Badawy , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c75301 _d75301