| 000 | 02887cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 191119s2019 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.01.Ph.D.2019.Ba.E | ||
| 100 | 0 | _aBassam Mohammed Ali Abdelwahab | |
| 245 | 1 | 0 |
_aEffect of some agents on testicular functions in a rat model of chronic mild stress-induced depression / _cBassam Mohammed Ali Abdelwahab ; Supervised Atef Tadros Fahim , Amal Ahmed Abdelfattah , Nermin Abdelhamid Sadik |
| 246 | 1 | 5 | _a(BIO 3.2.1) تأثير بعض المواد على وظائف الخصية ضد الإكتئاب الناجم عن الإجهاد المزمن فى نموذج للجرذان |
| 260 |
_aCairo : _bBassam Mohammed Ali Abdelwahab , _c2019 |
||
| 300 |
_a139 , (11) P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry | ||
| 520 | _aChronic stress occurs in everyday life and may lead to depression. Chronic stress is a major factor contributing to male infertility. Increasing evidence has demonstrated that resveratrol or dimethyl fumarate (DMF) has antioxidant and anti-inflammatory functions. The present study was designed to explore the possible protective effects of resveratrol or DMF against the testicular dysfunction associated with depressive brain in a rat model of chronic unpredictable mild stress (CUMS). Rats were subjected to 8 weeks of CUMS to induce depressive-like symptoms. CUMS-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal BDNF levels. CUMS significantly reduced sucrose preference and increased immobility time in stressed rats. CUMS exposure significantly decreased and increased expression levels of Ý-catenin and GSK-3Ý, respectively in the hippocampus and testes. Furthermore, CUMS exposure resulted in a significant increase in hippocampal and testicular expression levels of NF-mB, TNF-Ü and IL-1Ý and a significant decrease in Bcl-2 expression levels as well as a significant increase in testicular expression levels of Bax. CUMS caused a significant increase and decrease in levels of MDA and GSH, respectively in the hippocampus and testes as well as a significant decrease in serum total antioxidant capacity levels compared to the control group | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aChronic unpredictable mild stress | |
| 653 | 4 | _aDimethyl fumarate | |
| 653 | 4 | _aResveratrol | |
| 700 | 0 |
_aAmal Ahmed Abdelfattah , _eSupervisor |
|
| 700 | 0 |
_aAtef Tadros Fahim , _eSupervisor |
|
| 700 | 0 |
_aNermin Abdelhamid Sadik , _eSupervisor |
|
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c75307 _d75307 |
||