| 000 | 02629cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032447.0 | ||
| 008 | 191125s2019 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.03.M.Sc.2019.Do.P | ||
| 100 | 0 | _aDoaa Saeed Mohamed Zenhom | |
| 245 | 1 | 0 |
_aPossible association between microRNA-199a-5p and autophagy related genes in behcet disease / _cDoaa Saeed Mohamed Zenhom ; Supervised Rania Elsayed Hussein , Radwa Mohammed Gaber Ahmed , Mervat Mahmoud Eissa |
| 246 | 1 | 5 | _aالعلاقة المحتملة بين الحمض النووى الريبوزى المتناهى الصغر ١٩٩-٥ و جينات الالتهام الذاتى فى مرض بهجت |
| 260 |
_aCairo : _bDoaa Saeed Mohamed Zenhom , _c2019 |
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| 300 |
_a121 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry | ||
| 520 | _aBackground: Behcet disease (BD) is a relapsing inflammatory autoimmune disease. MicroRNAs are small RNA fragments that can regulate the gene expression. Autophagy is a protective and life-sustaining process in which cytoplasmic components are targeted to lysosomes for degradation. The aim of this work: To study the association between microRNA199a-5p and ATG5 and Behcet disease activity and severity. Methods: Relative expression of miRNA-199a-5p and ATG5 were measured by Real-Time PCR in blood samples obtained from 47 patients with BD and 50 matched healthy controls. Results: There was a significant higher ESR level in BD patients than controls which highly signifies its autoinflammatory predisposition. Also, there was a significant difference between patients and controls regarding the relative expression of microRNA 199a-5p (p<0.001) with lower expression in patients with BD than in healthy controls and it was significantly lower in patients with thrombophlebitis manifestation. ATG5 relative expression was significantly lower in patients with BD than in healthy controls and ATG5 was significantly higher in behcet patients with arterial thrombosis than other behcet patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAutophagy | |
| 653 | 4 | _aBehcet disease (BD) | |
| 653 | 4 | _aMicroRNA (miRNA) | |
| 700 | 0 |
_aMervat Mahmoud Eissa, _eSupervisor |
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| 700 | 0 |
_aRadwa Mohammed Gaber Ahmed , _eSupervisor |
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| 700 | 0 |
_aRania Elsayed Hussein , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c75447 _d75447 |
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