000			02838cam a2200313 a 4500
003			EG-GiCUC
008			191126s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.24.03.M.Sc.2019.Am.P
100	0		_aAmr Ehab Abdelrazik Kamel
245	1	2	_aA pharmaceutical study on the effect of photodynamic therapy to potentiate the anticancer activity of curcumin- loaded nano-systems on breast cancer cell line / _cAmr Ehab Abdelrazik Kamel ; Supervised Maha Fadel Mohamed , Dina Louis Nassif
246	1	5	_aدراسة ص{u٠٦أأ}دلان{u٠٦أأ}ة على تأث{u٠٦أأ}ر العلاج الضوئى الد{u٠٦أأ}نام{u٠٦أأ}كى لتحف{u٠٦أأ}ز النشاط المضاد للسرطان للكركم المحمل على الأنظمة النانو{u٠٦أأ}ة على خلا{u٠٦أأ}ا سرطان الثدى
260			_aCairo : _bAmr Ehab Abdelrazik Kamel , _c2019
300			_a81 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Application in Medical Biological
520			_aCurcumin (CUR) is a natural component derived from Curcuma longa L. that is known for its anticancer activity. Some problems limit the pharmaceutical usage of CUR, namely, low solubility, low bioavailability and photodegradation. However, being a photosensitizer, CUR stands as an attractive candidate for photodynamic therapy of cancer that overcomes major side effects associated with chemotherapy. Therefore, in this work, CUR was formulated into Nanostructures Lipid Carriers (NLCs) to enhance CUR cell penetration and effectiveness in cancer treatment. The work followed a 3x4 factorial design of two factors; one with three levels and the other with four levels. The first factor was the solid lipid type, where four solid lipids were used, namely, Peceol, Geleol, Compritol and Precirol. The second factor was the solid lipid to liquid lipid ratio which had three levels: 70:30, 85:15 and 95:5. Olive oil was chosen as the liquid lipid. Tween 80 and Lecithin were used as surfactant and cosurfactant, respectively. The factorial design resulted in 12 CUR-NLCs formulae that were prepared using High Shear Hot Homogenization method. The resulting CUR-NLCs were characterized by determining their particle size, polydispersity index, zeta potential, entrapment efficiency percent, drug loading percent and in vitro drug release
530			_aIssued also as CD
653		4	_aCancer
653		4	_aCurcumin
653		4	_aCurcuminoids
700	0		_aDina Louis Nassif , _eSupervisor
700	0		_aMaha Fadel Mohamed , _eSupervisor
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c75484 _d75484