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| 003 | EG-GiCUC | ||
| 005 | 20250223032448.0 | ||
| 008 | 191126s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.16.M.Sc.2019.So.P | ||
| 100 | 0 | _aSomaya Mahmoud Mohammed Balah | |
| 245 | 1 | 4 |
_aThe possible protective role of grape seeds extract versus folic acid on methotrexate induced liver injury in adult male albino rats / _cSomaya Mahmoud Mohammed Balah ; Supervised Mohammed Ahmed Abdelhafiz , Dalia Mohammed Elmarakby , Abeer Ibraheem Abdallah Omar |
| 246 | 1 | 5 | _aالتأثير الوقائى المحتمل لمستخلص بذور العنب الأحمر ضد حمض الفوليك على إصابة الكبد المستحدثه بعقار الميثوتريكسيت فى ذكور الجرذان المهق |
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_aCairo : _bSomaya Mahmoud Mohammed Balah , _c2019 |
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_a136 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology | ||
| 520 | _aBackground: Hepatic injury, a common complication of methotrexate (MTX) therapy, is followed by fibrosis. Activated hepatic stellate cells (HSCs) are responsible for such fibrosis. Folic acid (FA) reduces the incidence of MTX-liver toxicity meanwhile natural antioxidants are used without interfering the effectiveness. Aim of work: The study aimed at comparing the possible protective effect of grape seeds extract (GSE) and FA in a rat model of MTX-induced liver injury with a special reference on their influence on HSCs. Materials and methods: Thirty five adult male albino rats were divided into control, MTX, MTX-FA and MTX-GSE groups. Liver sections were stained with H&E, trichrome stain and immunohistochemical staining for Ü-smooth muscle actin (Ü-SMA) and glial fibrillary acidic protein (GFAP). Morphometric measurements of mean area percent of collagen fibers, Ü-SMA immune positive cells and GFAP immune positive cells were taken and statistically analyzed. Results: MTX group revealed marked with significant increase in the mean area percent of collagen, GFAP and Ü-SMA +ve cells. FA and GSE treated groups showed improvement in the hepatic lesions which was more obvious with GSE treatment. Conclusion: GSE had a better protective effect in reducing MTX-induced liver injury than FA | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHSCs | |
| 653 | 4 | _aLiver injury | |
| 653 | 4 | _aMTX | |
| 700 | 0 |
_aAbeer Ibraheem Abdallah Omar , _eSupervisor |
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| 700 | 0 |
_aDalia Mohammed Elmarakby , _eSupervisor |
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| 700 | 0 |
_aMohammed Ahmed Abdelhafiz , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aAsmaa _eCataloger |
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_aNazla _eRevisor |
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_2ddc _cTH |
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_c75485 _d75485 |
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