000			02920cam a2200349 a 4500
003			EG-GiCUC
005			20250223032451.0
008			191201s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.10.Ph.D.2019.Ra.M
100	0		_aRania Mohamed Sherif Mohamed Salah Eldin Ali Mogawer
245	1	0	_aMetabolic syndrome in early onset versus late onset vitiligo / _cRania Mohamed Sherif Mohamed Salah Eldin Ali Mogawer ; Supervised Samar Mohamed Ragai Eltahlawi , Marwa Safwat Elhawary , Sarah Ibrahim Ismail Ibrahim
246	1	5	_aمتلازمة الأيض فى مرضى البهاق و علاقتها بسن المريض عند ظهور المرض
260			_aCairo : _bRania Mohamed Sherif Mohamed Salah Eldin Ali Mogawer , _c2019
300			_a137 P. ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology
520			_aBackground: Systemic nature of vitiligo is gaining more concern starting by the associated autoimmune risk ending with the recently raised issue of the associated metabolic risk.Methods: This cross-sectional study included 150 vitiligo patients and 150 age and sex matched controls. Among the studied vitiligo patients, 57 were males (38%) and 93 were females (62%), 100 (66.7%) had non segmental vitiligo (NSV) and 50 (33.3%) had segmental vitiligo. They were assessed for Metabolic Syndrome (MetS) using International Diabetes Federation (IDF) in addition to insulin resistance via homeostasis model assessment of insulin resistance (HOMA-IR) in all patients and controls. In addition, Serum leptin was assessed in a randomly selected subgroup of patients and controls. Patients were further subdivided according to the age of onset into pre pubertal and post pubertal considering the different metabolic risk factors. Results: Vitiligo patients were found at higher metabolic risk. MetS was diagnosed in 37 (24.7%) of the vitiligo patients compared to 16 (10.7%) of the controls. In addition, vitiligo patients were found to have both insulin and leptin resistance. This proved true for both vitiligo patients with post pubertal and pre pubertal onset compared to their matched controls. Considering disease characteristics, metabolic risk was higher in patients with long vitiligo duration. However, it didn{u2019}t correlate with disease severity as per vitiligo area and severity Index (VASI) or body surface area (BSA)
530			_aIssued also as CD
653		4	_aAge of onset
653		4	_aMetS
653		4	_aVitiligo
700	0		_aMarwa Safwat Elhawary , _eSupervisor
700	0		_aSamar Mohamed Ragai Eltahlawi , _eSupervisor
700	0		_aSarah Ibrahim Ismail Ibrahim , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c75595 _d75595