| 000 | 03261cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032452.0 | ||
| 008 | 191202s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.19.Ph.D.2019.Sa.S | ||
| 100 | 0 | _aSabrin Mohamed Mohamed Abdelhamed Elkashef | |
| 245 | 1 | 0 |
_aSerum microRNA-21 and microRNA-155 as biomarkers for bronchial asthma / _cSabrin Mohamed Mohamed Abdelhamed Elkashef ; Supervised Sohair Elattar Ahmad , Marwa Salah Mostafa , Youssef Mohamed Amin Soliman |
| 246 | 1 | 5 | _aالحمض النووى الريبوزى المصغر 21 و الحمض النووى الريبوزى المصغر 155 بمصل الدم كمؤشرات حيوية فى الربو الشعبى |
| 260 |
_aCairo : _bSabrin Mohamed Mohamed Abdelhamed Elkashef , _c2019 |
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| 300 |
_a119 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology | ||
| 520 | _aBronchial asthma is an airway chronic disease characterized by Th2 inflammatory response and tissue remodeling after exposure to inhaled allergens. MicroRNAs (miRNAs) are short non-coding RNAs that are important regulators of gene expression of different immunological molecules. However, the role of miRNAs, specifically miRNA-21 and miRNA-155, in the regulation of allergic airway inflammation is unexplored. The aim of this study was to compare the serum expression levels of miRNA-21 and miRNA-155 in asthmatic patients with that of healthy controls and to correlate their levels with serum IL-4 levels. The study was conducted on 30 asthmatic patients and 30 healthy individuals who served as the control group. The expression levels of miRNA-21 and miRNA-155 were evaluated in the serum of both groups by quantitative reverse transcription PCR while serum levels of IL-4 were determined using the ELISA technique. Asthmatic patients showed significantly higher serum miRNA-21 (P < 0.001) and miRNA-155 (P < 0.001) expression levels and higher serum IL-4 levels (P < 0.001) compared to the controls. There was a statistically significant positive correlation between the expression levels miRNA-21 and IL4 serum levels in the asthmatic patients (rs = 0.609, P = < 0.001). However, no correlation was detected between the expression levels miRNA-155 and each of IL-4 (rs = 0.278, P = 0.136) and miRNA-21 (rs = 0.188, P = 0.321). MiRNA-21 and miRNA-155 are potential non-invasive biomarkers in asthma diagnosis and response to therapy. The effect of miRNA-21 and miRNA-155 on Th2 response and cytokine production can be mediated by different pathways. Further studies are required to investigate the role of miRNA-21 and miRNA-155 in the pathogenesis of different asthma phenotypes | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAsthma | |
| 653 | 4 | _aMiRNA-21 | |
| 653 | 4 | _aPathogenesis of asthma | |
| 700 | 0 |
_aMarwa Salah Mostafa , _eSupervisor |
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| 700 | 0 |
_aSohair Elattar Ahmad , _eSupervisor |
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| 700 | 0 |
_aYoussef Mohamed Amin Soliman , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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_c75614 _d75614 |
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