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| 003 | EG-GiCUC | ||
| 005 | 20250223032455.0 | ||
| 008 | 191209s2019 ua d f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2019.Ne.S | ||
| 100 | 0 | _aNehal Mohamed Mohamed Mansour | |
| 245 | 1 | 0 |
_aStudy of possible drug interactions between pravastatin and zofenopril in experimentally induced myocardial infarction in irradiated rats / _cNehal Mohamed Mohamed Mansour ; Supervised Mostafa E. Elsayed , Hala Fahmy Zaki , Seham Hassan Mohamed Hassan |
| 246 | 1 | 5 | _aدراسة التداخلات الدوائية المحتملة بين برافاستاتين و زوفينوبريل في الجرذان المشععةالمحدث لها إحتشاء بعضلة القلب |
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_aCairo : _bNehal Mohamed Mohamed Mansour , _c2019 |
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_a123 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aThe present work aimed to investigate the potential protective effect of zofenopril (ZF; 15 mg/kg/day; p.o.) and/or pravastatin (PR; 40 mg/kg/day; p.o.), respectively against isoprenaline (ISO)-induced acute myocardial infarction (AMI) in irradiated (IRR) rats. Rats were allocated into seven groups (n=10), (GP-I) normal-control group received distilled water, (GP-II) exposed to single dose (5Gy) gamma-irradiation, (GP-III) ISO group received ISO at doses of 85 and 170 mg/kg, subcutaneously, for 2 days with a 24-hr interval, (GP-IV) ISO-IRR group exposed to 5Gy IRR then received ISO at doses of 85 and 170 mg/kg, subcutaneously, for 2 days with a 24-hr interval, (GP-V) & (GP-VI) received ZF or PR, respectively, for 5days prior IRR and ISO, (GP-VII) received combined ZF and PR pretreatment for 5days prior IRR and ISO. Parameters for evaluation the protective effect of the tested drugs included serum levels of tumor necrosis factor-alpha (TNF-Ü), high-sensitivity C-reactive protein (Hs-CRP) and activities of creatine kinase (CK-MB), lactate dehydrogenase (LDH) andaspartate transaminase (AST) as well as lipid profile, in addition to, cardiac tissue activities of superoxide dismutase (SOD) and catalase and levels of malondialdehyde (MDA) and glutathione (GSH). Histopathological examination of cardiac tissue was also carried out | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAcute myocardial infarction | |
| 653 | 4 | _aPravastatin | |
| 653 | 4 | _aZofenopril | |
| 700 | 0 |
_aHala Fahmy Zaki , _eSupervised |
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| 700 | 0 |
_aMostafa E. Elsayed , _eSupervised |
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| 700 | 0 |
_aSeham Hassan Mohamed Hassan , _eSupervised |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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_c75724 _d75724 |
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