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| 003 | EG-GiCUC | ||
| 008 | 191225s2019 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.21.Ph.D.2019.Sh.P | ||
| 100 | 0 | _aShaymaa Mohamed Eissa Eldoh | |
| 245 | 1 | 0 |
_aPotential genotoxicity and anti-tumor activity in tumor-bearing mice treated with zinc oxide nanoparticles and N-acetyl cysteine / _cShaymaa Mohamed Eissa Eldoh ; Supervised Mohamed Akmal Elghor , Salwa Farouk Sabet , Haidan Mostafa salem |
| 246 | 1 | 5 | _aالسميه الجنينيه المحتملة ووالنشاط المضاد للتورم فى الفئران الحاملة للورم والمعاملة بجسيمات أكسيد الزنك النانونية ون -أسيتيل سيستين |
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_aCairo : _bShaymaa Mohamed Eissa Eldoh , _c2019 |
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| 300 |
_a126 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology | ||
| 520 | _aBackground: Several in vitro studies have revealed that zinc oxide nanoparticles (ZnONPs) were able to target cancerous cells selectively with minimal damage to healthy cells. In the current study, we aimed to evaluate the antitumor activity of ZnO-NPs in Ehrlich solid carcinoma (ESC) bearing mice by measuring their effect on the expression levels of P53, Bax and Bcl2 genes as indicators of apoptotic induction in tumor tissues. Also, we assessed the potential ameliorative or potentiation effect of 100 mg/kg of N-acetyl cysteine (NAC) in combination with ZnO-NPs. Materials and methods: ESC bearing mice were gavaged with three different doses of ZnO-NPs (50, 300 and 500 mg/kg body weight) alone or in combination with NAC for seven consecutive days. In addition to measuring the tumor size, pathological changes, zinc content, oxidative stress biomarkers and DNA damage in ESC, normal muscle, liver and kidney tissues were assessed. Results: Data revealed a significant reduction in tumor size with a significant increase in p53 and Bax and decrease in Bcl2 expression levels in the tissues of ZnO-NPs treated ESC bearing mice. Moreover, a significant elevation of MDA accompanied with a significant reduction of CAT and GST | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAntitumor | |
| 653 | 4 | _aEhrlich Solid Carcinoma (ESC) | |
| 653 | 4 | _aZinc oxide nanoparticles (ZnO-NPs) | |
| 700 | 0 |
_aHaidan Mostafa salem , _eSupervisor |
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| 700 | 0 |
_aMohamed Akmal Elghor, _eSupervisor |
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| 700 | 0 |
_aSalwa Farouk Sabet , _eSupervisor |
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c76084 _d76084 |
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