| 000 | 02460cam a2200337 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032507.0 | ||
| 008 | 191228s2019 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2019.Ay.P | ||
| 100 | 0 | _aAyman Abdelaziz Ibrahim Abdelaziz Eltantawy | |
| 245 | 1 | 4 |
_aThe possible pharmacological effect of a certain antioxidant against gamma radiation-inducedtesticular toxicity in rats / _cAyman Abdelaziz Ibrahim Abdelaziz Eltantawy ; Supervised Mohammed F. Elyamany , Esmat A. Shaaban |
| 246 | 1 | 5 | _aالتأثير الدوائى المحتمل لمضاد اكسدة معين ضد تسمم الخصية المحدث بالإشعاع الجامى فى الجرذان |
| 260 |
_aCairo : _bAyman Abdelaziz Ibrahim Abdelaziz Eltantawy , _c2019 |
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| 300 |
_a94 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aAims: The deleterious effect of gamma radiation on testicular tissue is a challenging problem in nuclear medicine. This study investigated the potential radioprotective and curative effects of Mitoquinol (MitoQ), a mitochondria-targeted antioxidant, against testicular damage induced by gamma irradiation in rats. Main methods: firstly, a pilot study was conducted to select the most effective dose of MitoQ via estimation of sperm features, testicular caspase-3 along with histological evaluation. The investigated doses were (0.5, 1, 2, 5 & 10) mg/kg/day; i.p. for seven days before gamma irradiation (5 Gray as a single dose) and the most effective dose was 2 mg/kg/day. Then, main study was performed where rats were allocated into five groups. The first group served as the control, the second group received MitoQ (2 mg/kg/day; i.p.) for seven days, the third group was exposed to gamma radiation (5 Gray as a single dose), the fourth group received MitoQ prior to irradiation and the last group received MitoQ after irradiation | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aApoptosis | |
| 653 | 4 | _aMitochondria-targeted antioxidant | |
| 653 | 4 | _aMitoQ | |
| 700 | 0 |
_aEsmat A. Shaaban , _eSupervisor |
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| 700 | 0 |
_aMohammed F. Elyamany , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c76112 _d76112 |
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