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003 EG-GiCUC
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008 191230s2018 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.09.12.M.Sc.2018.Na.D
100 0 _aNada Ahmad Mohammad
245 1 0 _aDevelopmental & innervation changes in circumvallate papilla of untreated diabetic rats' offspring versus turmeric treated diabetic rats' offspring :
_bAn animal study /
_cNada Ahmad Mohammad ; Supervised Zoba Hassan Ali , Marwa Magdy Saad
246 1 5 _aالتغيرات التكوينية والعصبية لحليمة اللسان المحوطة فى ذرية الفئران المصابة بالسكرى والغير معالجة مقاب لذرية الفئران المصابة بالسكرى والمعالجة بجذور الكركم
260 _aCairo :
_bNada Ahmad Mohammad ,
_c2018
300 _a174 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology
520 _aObjectives: The current study was performed to investigate the effect of maternal diabetes on the development and the innervation of circumvallate tongue papillae in their offspring and possible beneficial effect of turmeric administration to the diabetic mother in preventing the defective development. Design: The study was carried on 60 pups from diabetic mother rats that were classified in 2 main groups; group I; untreated diabetic mother rats and group II; diabetic mother rats treated with 30 mg/kg turmeric by oral gavage. The pups were sacrificed at three different ages. The circumvallate papillae were dissected and examined histologically, immunohistochemically for S100 and as well as histomorphometrically.Results: The histopathological results revealed deformed outline of the papillae in the untreated rats{u2019} offspring, decreased number of well-formed taste buds, degenerative effects in Remak{u2019}s ganglion and decreased innervation.Immunohistochemical results showed significant differences between untreated & Turmeric treated groups in terms of S100 expression. Conclusion: Maternal diabetes has a degenerative effect on the taste system of the offspring including the taste buds itself and their intrinsic nervous system and the offspring of diabetic mothers had less number of taste buds and defective innervation than controls and whose mothers were treated with turmeric
530 _aIssued also as CD
653 4 _aAdvanced glycation end products (AGEs)
653 4 _aCircumvallate papilla
653 4 _aInnervation changes
700 0 _aMarwa Magdy Saad ,
_eSupervisor
700 0 _aZoba Hassan Ali ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c76165
_d76165