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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.19.04.M.Sc.2019.Fa.P
100 0 _aFatma Sami Eissa
245 1 0 _aPrognostic value of metformin in locally advanced irresectable non small cell lung cancer patients /
_cFatma Sami Eissa ; Supervised Ahmed Elsaied Elbastawisy , Shereen Mostafa Elshorbagy , Rimon Ramsis Anis
246 1 5 _aالنتائج والسمات التنبؤية لعقار الميتفورمين فى مرضي المصابين بسرطان الرئة المتقدم محليا والغير قابل للاستئصال
260 _aCairo :
_bFatma Sami Eissa ,
_c2019
300 _a101 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical)
520 _aLocally advanced NSCLC is frequently inoperable and treated with combined chemoradiotherapy with poor outcomes due to high resistance to chemotherapy. Metformin, a first line anti diabetic medication, was found to have an anti-tumor effect. The study is a prospective study evaluating the efficacy and toxicity of adding metformin to concomitant chemo-radiotherapy using platinum based chemotherapy (paclitaxel 45mg\m2,carboplatin AUC 2 weekly with thoracic radiation of 60 Gy in 30 fractions over 6 weeks in locally advanced irresectable non small cell lung cancer patients. We enrolled 30 patients of locally advanced irresectable lung cancer patients and divided into two groups . Group A included 15 patients received concomitant chemo-radiotherapy with metformin and group B received concomitant chemo-radiotherapy without metformin and concluded no statistically significant difference were found between the two groups as regard clinical response and over all clinical benefit and was tolerable. Adding metformin to concurrent in locally advanced irresectable NSCLC patients improved the PFS but did not effect the OS at one year follow up
530 _aIssued also as CD
653 4 _aChemoradiotherapy
653 4 _aMetformin
653 4 _aNSCLC
700 0 _aAhmed Elsaied Elbastawisy ,
_eSupervisor
700 0 _aRimon Ramsis Anis ,
_eSupervisor
700 0 _aShereen Mostafa Elshorbagy ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c76260
_d76260