000			03153cam a2200337 a 4500
003			EG-GiCUC
005			20250223032514.0
008			200115s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2019.Sa.F
100	0		_aSara Abdelmoniem Abdelbary Marzok
245	1	0	_aFormulation and characterization of an in situ gelling ocular system for treatment of glaucoma / _cSara Abdelmoniem Abdelbary Marzok ; Supervised Magdy Ibrahim Mohammed , Abeer Mostafa Khattab
246	1	5	_aصياغة وتوصيف نظام هلامى لعلاج ضغط العين المرتفع
260			_aCairo : _bSara Abdelmoniem Abdelbary Marzok , _c2019
300			_a165 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aGlaucoma or high intraocular pressure (IOP) is an ocular disease that occurs when the balance between the amounts of the intraocular fluid produced and the amount that drains away is disturbed. This causes high fluid pressure in front of the eye and leads to deterioration of the optic nerve. If the IOP is not well cared and controlled, a progressive visual loss and blindness may occur. Latanoprost, a prostaglandin analogue, is an effective ocular hypotensive agent and has the longest duration of action. Latanoprost is a prodrug, once it was administrated topically, it permeates the cornea where it is enzymetically transformed to the active Latanoprost acid. This active form is released into the interior chamber and reaches the iris-ciliary body where it achieves its therapeutic effect. The mechanism of action of this active acid to reduce the IOP is to increase outflow of aqueous humor through the uveoscleral drainage pathway (uveoscleral drainage refers to the drainage of ocular aqueous humor from the anterior chamber into the anterior chamber angle). It has been reported that less than 7% of Latanoprost really reach the site of action due to its short contact time. Therefore, the application of the Latanoprost drop in the eye many times is required to attain the therapeutic effect of the drug. This could expose the eye to the excessive amount of preservatives which may cause irritation, burning, or dryness of the ocular surface. In the recent years, the pharmaceutical scientist intended to formulate a dosage form that circumvents the eye's protective barriers with no damage of tissues. The popular conventional ocular dosage forms such as eye drops (solution and suspension) have various limitations such as the short residence time, large drainage factor due to the high tear fluid turnover, pulsed dosing of drug and poor bioavailability
530			_aIssued also as CD
653		4	_aControlled release
653		4	_aLatanoprost
653		4	_aPluronic F127
700	0		_aAbeer Mostafa Khattab , _eSupervisor
700	0		_aMagdy Ibrahim Mohammed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c76352 _d76352