| 000 | 02494cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032519.0 | ||
| 008 | 200203s2020 ua h f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.05.Ph.D.2020.Ma.D | ||
| 100 | 0 | _aMarwa Arafa Ibrahim Abdelaziz | |
| 245 | 1 | 0 |
_aDesign and synthesis of histone deacetylase inhibitors (HDACIs) as anticancer agents / _cMarwa Arafa Ibrahim Abdelaziz ; Supervised Samir Mohamed Elmoghazy , Sahar Mahmoud Abouseri , Riham François George |
| 246 | 1 | 5 | _aتصميم و تشييد مثبطات الانزيم هيستون دى-أستيلاز كمضادات للسرطان |
| 260 |
_aCairo : _bMarwa Arafa Ibrahim Abdelaziz , _c2020 |
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| 300 |
_a196 P. : _bfacsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aIn a search for new anticancer candidates, and motivated by the pivotal role of class III histone deacetylase (Sirtuins) in the occurrence and development of a variety of diseases including cancer, in addition to the promising anticancer activity exhibited by SIRT2 inhibitors, it deemed of interest to design and synthesize new series of phenolic azomethine derivatives and 5-arylidene thiazolidinones as novel anticancer SIRT2 inhibitors. In this regards, docking studies were performed to support the implemented design strategies. The synthesized target compounds were subjected to SITR2 enzyme inhibitory assay. Additionally, in vitro cytotoxic activities of the targeted compounds were tested in the NCI-60 human tumor cell line anticancer drug screening program, subsequently their selective cytotoxicity against the lung cancer cell line HOP-92 and the brain cancer cell line SNB-75 was assayed. Furthermore, the most active compounds were then tested for their effect on the cell cycle and apoptotic induction activity, in addition to their growth inhibitory activity against the human normal lung fibroblast cell line WI-38 | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAnticancer | |
| 653 | 4 | _aApoptosis | |
| 653 | 4 | _aSirtuins | |
| 700 | 0 |
_aRiham François George , _eSupervisor |
|
| 700 | 0 |
_aSahar Mahmoud Abouseri , _eSupervisor |
|
| 700 | 0 |
_aSamir Mohamed Elmoghazy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c76501 _d76501 |
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