000			02742cam a2200325 a 4500
003			EG-GiCUC
008			200206s2020 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.02.Ph.D.2020.En.P
100	0		_aEngy Maged Mohamed Shams Eldin
245	1	0	_aProtective effect of ginger and rosemary on diethylnitrosamine toxicity in rats / _cEngy Maged Mohamed Shams Eldin ; Supervised Abdelgawad Ali Fahmi , Ali Ibrahim Said Ahmed , Naglaa Hassanen Mohamed Hassanen
246	1	5	_aالتأثير الوقائى للزنجبيل واكليل الجبل على سميه ثنائى ايثيل نيتروزو امين فى الفئران
260			_aCairo : _bEngy Maged Mohamed Shams Eldin , _c2020
300			_a190 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aLiver injury caused by viruses, toxic chemicals, certain drugs and environmental pollutants has been increasing over the past few decades. Nitrosamine was known to be a carcinogenic compound; however, it is widely used in industrial solvents.This compound is involved in various food including milk, meat, salted fish, alcoholic beverages and many vegetables. Whatever the source of nitrosamine compound, it has harmful effects with respect to human and animals. Our research aims to study the protective effect of ginger and rosemary and their essential oils towards many vital body functions such as liver and kidney functions as well as lipid profile and oxidation level in the serum of rats induced with diethylnitrozamine compared with the traditional treatment (Silymarin: 52 mg/kg of diet). Methods This study comprise both in vitro and in vivo investigations. In vitro part includes identification of chemical composition of the dried plants using HPLC and essential oil constituents using GC-MS; antioxidant properties of the dried plants and their essential oils were measured via several antioxidant activity tests. In vivo part includes evaluation of the hepatoprotective effect of ginger and rosemary on DEN-induced liver and kidney injury in rats. In which the effect dried plants or their essential oils were applied and compared with that of silymarin, as a standard reference drug
530			_aIssued also as CD
653		4	_aDiethylnitrosamine toxicity
653		4	_aEssential oil
653		4	_aGinger
700	0		_aAbdelgawad Ali Fahmi , _eSupervisor
700	0		_aAli Ibrahim Said Ahmed , _eSupervisor
700	0		_aNaglaa Hassanen Mohamed Hassanen , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c76539 _d76539