000			03212cam a2200349 a 4500
003			EG-GiCUC
005			20250223032521.0
008			200206s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.01.M.Sc.2020.Am.C
100	0		_aAmira Essam Eldin Zaki Mady
245	1	0	_aCrosstalk between long noncoding rnas and MicroRNAs in hepatitis B virus (HBV) infected Egyptian patients / _cAmira Essam Eldin Zaki Mady ; Supervised Tarek Mohamed Kamal Motawi , Sherine Maher Rizk , Soha Zaki Elshenawy
246	1	5	_aالتداخل بين الأحماض النووية الريبوزية الطويلة الغير مشفرة مع الأحماض النووية الريبوزية المتناهية الصغر للمرضى المصريين المصابين بمرض الالتهاب الكبدى الفيروسى ب
260			_aCairo : _bAmira Essam Eldin Zaki Mady , _c2020
300			_a106 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
520			_aIn the last decades, the perception of non-coding RNAs (ncRNAs) was changed from being as junk transcriptional products to acting as a functional epigenetic regulator of genes due to their crucial roles in regulating various biological and pathological processes. ncRNAs encompassed major classes like the well-known microRNAs (miRNAs) and the most recently acknowledged long non- coding RNAs (lncRNAs). Previous studies have revealed a complicated interplay between many miRNAs and LncRNAs. This miRNA-LncRNA crosstalk was involved in a great number of human diseases such as Hepatitis infection. Circulating microRNAs have a vital role in Hepatitis B virus (HBV) diagnosis and therapeutics. miR-100 was reported to be associated with various aspects of HBV biology. This study focused on microRNA-100 (miR-100) and Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) Single Nucleotide Polymorphisms (SNPs) and their contribution to an individual's susceptibility and prognosis of HBV infection correlated to their expression level. The effect of these SNPs on their expression levels was also evaluated on 200 subjects divided into 100 HBV infected patients versus 100 age-and-sex- matched healthy individuals served as a control group. SNP detection was performed using polymerase chain reaction sequence-specific primer technique (PCR-SSP) for miR-100 SNP rs1834306 T/C while for MALAT1 SNP rs619586A/G was detected using restriction fragment length polymorphism-PCR (RFLP-PCR) techniques. miR-100 and MALAT1 expressions were measured by quantitative real-time PCR (qRT-PCR) Egyptian population
530			_aIssued also as CD
653		4	_aHepatitis B Virus (HBV)
653		4	_aMicro RNA (miRNA)
653		4	_aSingle nucleotide polymorphisms (SNP)
700	0		_aSherine Maher Rizk , _eSupervisor
700	0		_aSoha Zaki Elshenawy , _eSupervisor
700	0		_aTarek Mohamed Kamal Motawi , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c76560 _d76560