000			03295cam a2200349 a 4500
003			EG-GiCUC
005			20250223032536.0
008			200728s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.28.Ph.D.2020.Mo.E
100	0		_aMona Ahmed Sayed Atteya Gabr
245	1	0	_aEffect of growth hormone therapy on the development of metabolic syndrome and on cardiac functions and dimensions in patients with turner syndrome / _cMona Ahmed Sayed Atteya Gabr ; Supervised Abeer Atef Mohammed Alshmawy , Inas Abdelsattar Saad , Nora Elsaid Mohamed Badawi
246	1	5	_aتأثيرالعلاج بهرمون النموعلى تطور متلازمة الأيض و وظائف و مقاسات القلب في المرضى الذين يعانون من متلازمة تيرنر
260			_aCairo : _bMona Ahmed Sayed Atteya Gabr , _c2020
300			_a163 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Growth hormone (GH) may positively affect body composition and body mass index in patients with Turner syndrome (TS). The study aims to compare blood pressure, lipid profile, fasting blood glucose, insulin resistance, waist circumference (WC) and cardiac functions between TS patients before and after GH therapy. Methods: The study included 54 TS patients; 29 after beginning GH therapy (cases) and 25 before initiating GH therapy (serving as controls). Their ages ranged from 6.01 years to 17.1 years. Anthropometric measures, skin fold thickness measurements, body composition analysis and blood pressure were recorded. Fasting lipid profile, fasting blood glucose, fasting insulin, fasting c-peptide, liver enzymes and thyroid profile were studied. Complete two-dimensional, M-mode, pulsed-wave Doppler echocardiography, pulsed-wave tissue Doppler imaging (TDI) and abdomino-pelvic ultrasound were done. Results: Cases had higher WC SDS for age, hip circumference, bone mass, high density lipoprotein cholesterol (HDL-C), myocardial performance index of left and right ventricles and S' wave in the septal wall of left ventricle (reflecting global impairment of myocardial function). One patient who had received GH and two controls fulfilled international diabetes feredration criteria of metabolic syndrome. The patients' age at start of GH therapy correlated negatively with height SDS for age and muscle percentage and positively with triglyceride levels.The cholesterol levels correlated positively with diastolic blood pressure percentiles. Insulin resistance was positively correlated with WC SDS and sum of skin fold thickness percentiles. Fasting c- peptide level was positively correlated with systolic blood pressure percentiles
530			_aIssued also as CD
653		4	_aGrowth hormone
653		4	_aTurner syndrome
653		4	_aWaist circumference
700	0		_aAbeer Atef Mohammed Alshmawy , _eSupervisor
700	0		_aInas Abdelsattar Saad , _eSupervisor
700	0		_aNora Elsaid Mohamed Badawi , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c77046 _d77046