| 000 | 02662cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032540.0 | ||
| 008 | 200811s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.03.M.Sc.2020.Na.A | ||
| 100 | 0 | _aNahla Nasser Mohamed | |
| 245 | 1 | 0 |
_aAnalytical study of selected alpha adrenoceptors blockers / _cNahla Nasser Mohamed ; Supervised Badr Elzeiny , Mohammed Abdelkawy , Taghreed Abdelfattah |
| 246 | 1 | 5 | _aدراسة تحليلية لمركبات مختارة لمثبطات مستقبلات الألفا الأدرينالينية |
| 260 |
_aCairo : _bNahla Nasser Mohamed , _c2020 |
||
| 300 |
_a208 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry | ||
| 520 | _aThis thesis is concerned with analytical study of twoÜ-adrenoceptors blockers, either alone as Silodosin or inco-formulated mixture as Tamsulosin HCl withDeflazacort. In this work, various analytical methods were developedfor the stabilityindicating determination of the studied drug Silodosinusingspectroscopicand chromatographic techniques. Different experimental conditions were optimized for each proposed method. Forced degradation studies were performed on Silodosin for identification of possible degradation pathways of the drug and demonstration of the ability of the proposed methods to specifically determine the drug in the presence of its degradation products. For the determination of Tamsulosin HCl in mixture with Deflazacort,efforts were devoted towards establishment of more eco-friendly analytical methods, through use of greener solvents in chromatographic separationorminimizationof waste generation and sample pretreatment steps inanalysis by ion selective electrode.The validity ofthe developed methods wasperformed accordingto ICH guidelines.Comparative studies were also done between the proposed methods and the official or reported ones.The suggested methodswere successfully applied for the analysis of the studied drugs either in theiravailable pharmaceutical dosage forms, dissolution media , or in biological fluids | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAlpha adrenoceptors blockers | |
| 653 | 4 | _aSilodosin | |
| 653 | 4 | _aTamsulosin HCl | |
| 700 | 0 |
_aBadr Elzeiny , _eSupervisor |
|
| 700 | 0 |
_aMohammed Abdelkawy , _eSupervisor |
|
| 700 | 0 |
_aTaghreed Abdelfattah , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c77174 _d77174 |
||