| 000 | 02783cam a2200337 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032540.0 | ||
| 008 | 200811s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.02.Ph.D.2020.Di.B | ||
| 100 | 0 | _aDina Mostafa Mohammed Mohammed | |
| 245 | 1 | 0 |
_aBiochemical studies on the relation between tamoxifen, nano-nutrients and some bioactive components and gene expression in experimental breast cancer / _cDina Mostafa Mohammed Mohammed ; Supervised Abdou Osman Abdelhamid , Afaf Ezzat Abbas |
| 246 | 1 | 5 | _aدراسات بيوكيميائية عن العلاقة بين التاموكسفين: المغذيات النانو وبعض المركبات النشطة حيويا والتعبير الجينى فى سرطان الثدى التجريبي |
| 260 |
_aCairo : _bDina Mostafa Mohammed Mohammed , _c2020 |
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| 300 |
_a289 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry | ||
| 520 | _aThis work had been carried out to study converting drug (Tamoxifen), some nutrients (yeast) and bioactive compounds (Silymarin and Isoflavone) to nanoparticles and study their different effects in nano and normal scale on gene expression. Encourage the use of nanotechnology to limit the development and spread of breast cancer and the inhibitory effect of them on development of toxic material of mammary tumor for 180 days against with a single oral dose of (25 mg/kg) 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. The body weight and food consumption will be examined. Upon the completion of the study, the histopathological studies on the breast tissues will be performed. The therapeutic and protective effects of these compounds in nano and normal scale will be evaluated using the appropriate parameters to determine the level of several chemicals related to oxidative damage (8-OHdG, Lipid Peroxide, TAC), Apoptosis, Plasma Estrogen and ErbB-2 in the blood samples. Also, the gene expression of ErbB-2 will be investigated in the blood samples. Finally, all the experimental results evaluated, tabulated and statistically analyzed. In conclusion, Breast cancer is highly curable if diagnosed with nutrients or medications whether in their normal or nano particles form at an early stage | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBioactive Components | |
| 653 | 4 | _aBreast Cancer | |
| 653 | 4 | _aExperimental Rats | |
| 700 | 0 |
_aAbdou Osman Abdelhamid , _eSupervisor |
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| 700 | 0 |
_aAfaf Ezzat Abbas , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c77182 _d77182 |
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