000			02716cam a2200313 a 4500
003			EG-GiCUC
008			200818s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2019.Ha.T
100	0		_aHanan Khairy Abouarab
245	1	0	_aTherapeutic efficacy of osthole on dinitrobenze sulphonic acid induced-colitis in rats / _cHanan Khairy Abouarab ; Supervised Mohamed Asem Said Marie , Abeer Mahamoud Badr , Hanan Mohamed Ebead Saleh
246	1	5	_aالكفاءه العلاجيه للاوزول على التهاب القولون المستحث بدينيتروبنزين حمض السلفونيك فى الجرذان
260			_aCairo : _bHanan Khairy Abouarab , _c2019
300			_a110 P. : _bcharts , facsmailies; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aSeveral mediators were associated with the pathogenesis of inflammatory bowel disease such as oxidative stress through the production of reactive oxygen metabolites, neutrophils infiltration and release of pro-inflammatory cytokines. This study was designed to investigate the therapeutic efficacy of osthole against dinitrobenzene sulfonic acid (DNBS) induced-colitis in rats through its anti- oxidant and anti-inflammatory properties. Colitis was induced in rats by single intracolonic instillation of (250 ol DNBS-25 mg/rat). Then 4 days later, rats were received oral administration of either (osthole 50 mg/kg), (sulfasalazine 500 mg/kg) or both in combination for 7 consecutive days. Body weight, some hematological parameters, colonic malondialdehyde (MDA) and myeloperoxidase activity (MPO), antioxidant parameters, colon injury and mucosa architectures were assessed. T helper (Th1)-related cytokines [Tumor necrosis factor alpha (TNF-Ü) and interferon-gamma (INF-Þ)], Th2-relarted cytokines (interleukin-4 [IL- 4 and IL-10], and Th-17 related cytokines [IL-17] were determined by ELISA. Osthole significantly improved the loss in body weight. That was accompanied with a remarkable amelioration of the disruption of the colonic architecture as well as a significant improvement in the antioxidant defense system. A reduction in MPO and MDA was observed in flamed colon
530			_aIssued also as CD
653		4	_aOsthole Colitis DNBS Antioxidants
653		4	_aSulfasalazine Cytokines
700	0		_aAbeer Mahamoud Badr , _eSupervisor
700	0		_aHanan Mohamed Ebead Saleh , _eSupervisor
700	0		_aMohamed Asem Said Marie , _eSupervisor
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c77269 _d77269