000			02136cam a2200337 a 4500
003			EG-GiCUC
005			20250223032543.0
008			200819s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.02.M.Sc.2020.Ay.D
100	0		_aAya Mohamed Abdelghany Ahmed
245	1	0	_aDevelopment of biodegradable polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori / _cAya Mohamed Abdelghany Ahmed ; Supervised Mohamed Ali Eldesouky ,Mohamed Abbas Shemis
246	1	5	_aتطوير كبسولات بوليمارية متناهية الصغر قابلة للتحلل البيولوجى لنقل الدواء الذى يستهدف الميكروب الحلزونى
260			_aCairo : _bAya Mohamed Abdelghany Ahmed , _c2020
300			_a95 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aIn this study we used double emulsion technique to prepare spherical shaped polymeric nanocapsules composed of amoxicillin trihydrate as the core substance and a biodegradabe biocompatible poly ({uF065}-caprolactone) as the shell material. The hydrodynamic diameter of the prepared nanocapsules was 287 ± 8 nm with positive zeta potential. In vitro release study indicated that the polymeric nanocapsules showed the least release at pH 1.2 simulating the gastric fluid while increasing release at pH 7.0 where the H. pylori resides. The in vitro antibacterial assay showed better efficiency for Amoxicillin nanocapsules than the free drug. Cytotoxicity studies showed least cytotoxicity for the polymeric nanocapsules in comparison to the amoxicillin
530			_aIssued also as CD
653		4	_aDouble emulsion
653		4	_aH. pylori
653		4	_aPolymeric nanocapsules
700	0		_aMohamed Abbas Shemis , _eSupervisor
700	0		_aMohamed Ali Eldesouky , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c77292 _d77292