| 000 | 02445cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032544.0 | ||
| 008 | 200822s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.19.03.Ph.D.2020.La.N | ||
| 100 | 0 | _aLamiaa Nabih Helal Elfadali | |
| 245 | 1 | 0 |
_aNucleophosmin mutations in De novo adult acute myeloid leukemia and its prognostic impact / _cLamiaa Nabih Helal Elfadali ; Supervised Khaled Mostafa Aboulenein , Naglaa Mostafa Hassan Ahmed , Raafat Mohammad Abdelfattah |
| 246 | 1 | 5 | _aدراسة تكرار طفرة جين النيوكليوفوزمين فى حالات سرطان الدم الميلودى الحاد الجديدة لدى البالغين |
| 260 |
_aCairo : _bLamiaa Nabih Helal Elfadali , _c2020 |
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| 300 |
_a143 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology | ||
| 520 | _aAim:To evaluate the frequency of NPM mutation A in denovo adult AML and to evaluate its relation with clinical and laboratory parameters and with response to treatment. Patients and Methods: 89 patients were included in our study, taking BM samples, RNA extraction and quantitative RT-PCR were done to detect the frequency of NPM1 mutation A. Results:We found NPM1 mutation in 33/89 (37.1) AML patients of which NPM mutation A was found in 6/33 (18.1%) NPM mutated AML patients and was 6/89 (6.7%) of AML patients. 24/33 (72.7%) NPM mutated patients were died before day 28 of treatment. 9/33 (27.3%) NPM mutant patients achieved CR. 5/6 (83.3%) NPM mutation A patients died before D28 of treatment and 1/6 (6.7%) NPM mutation A patient achieve CR with no statistically significance. Conclusions:We found that frequency of NPM gene mutation was 37% of AML patients and NPM gene mutation A was 18% of NPM1 mutation and 6.7 of AML patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aActivities of daily living (ADL) | |
| 653 | 4 | _aAcute myeloid leukemia | |
| 653 | 4 | _aNucleophosmin gene mutation | |
| 700 | 0 |
_aKhaled Mostafa Aboulenein , _eSupervisor |
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| 700 | 0 |
_aNaglaa Mostafa Hassan Ahmed , _eSupervisor |
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| 700 | 0 |
_aRaafat Mohammad Abdelfattah , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c77305 _d77305 |
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