000			03532cam a2200349 a 4500
003			EG-GiCUC
005			20250223032544.0
008			200822s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.19.05.M.Sc.2020.Mo.P
100	0		_aMohamed Magdy Mohamed Refai
245	1	0	_aPattern and outcome of renal neoplasms in children above 5 years and adolescents : _bA ten-years{u2019} experience, a single-institution study / _cMohamed Magdy Mohamed Refai ; Supervised Wael Zekri Khaled , Sayed Abdelhamid , Eman Naguib Khorshed
246	1	5	_aتحليل نمط و نتائج حالات اورام الكلى فى الاطفال والبالغين البالغ اعمارهم اكبر من 5 سنوات المعهد القومي للأورام : مصر
260			_aCairo : _bMohamed Magdy Mohamed Refai , _c2020
300			_a189 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aBackground: Malignant renal tumors account for 7% of childhood cancers and Wilms{u2019} tumor is by far the most common renal neoplasm in the pediatric population. However, the majority of these tumors are diagnosed before the patient is aged 5 years, it is now believed that renal tumors in older children differ from their counterparts in young patients in clinical behavior, biology, histology, and the long term outcome. In particular, renal cell carcinoma, primitive neuroectodermal tumor, anaplastic Wilms{u2019} tumors, and primary renal synovial sarcoma are relatively more frequent in older children and adolescents. Among children above 5 years, a poorer prognosis has been associated with a higher prevalence of unfavorable histology, advanced disease stage and different aggressive tumor types. Purpose: The aim of this study is to analyze different aspects of renal tumors in children aged above 5 years, and to compare the disease characteristics, treatment approach and outcome with the previously published literature. Methods: This is a retrospective study included pediatric patients aged 5-18 years diagnosed with primary renal tumors, treated at NCI, between January 2008 and December 2017. Medical records of all patients were reviewed for demographic profile, clinical features, imaging studies, management and treatment outcome. Patients were followed up till December 2018. Results: There were 47 patients (20%) with renal tumors in children aged 5-18 years, with the majority of them aged below 10 years (80%). Wilms{u2019} tumor is the most common histology (80.9%) but only nine patients had non-Wilms{u2019} tumors (19%), most of the Wilms{u2019} tumor cases had favorable histology (FH) (87%),and only five patients had unfavorable histology (13%). Among the Non-Wilms{u2019} tumors, Renal cell carcinoma (RCC), clear cell sarcoma, Primitive neuroectodermal tumor (PNET) and synovial sarcoma were found in two cases for each one (4.3% for each type), and one case of undifferentiated sarcoma (2.1%)
530			_aIssued also as CD
653		4	_aOlder Children
653		4	_aRenal Tumors
653		4	_aWilms{u2019} tumor
700	0		_aEman Naguib Khorshed , _eSupervisore
700	0		_aSayed Abdelhamid , _eSupervisor
700	0		_aWael Zekri Khaled , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c77324 _d77324