000			03170cam a2200349 a 4500
003			EG-GiCUC
005			20250223032552.0
008			200905s2020 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.19.05.Ph.D.2020.Af.P
100	0		_aAfaf Mohammad Mahmoud
245	1	0	_aPrognostic significance of suryiyin expression in pediatric ewing sarcoma family of tumors at National Cancer Institute, Egypt / _cAfaf Mohammad Mahmoud ; Supervised Lobna Mohamed Shalaby , Wael Zekri Khaled , Eman Naguib Khorshed
246	1	5	_aالقيمة التنبؤية للسرفيفين فى أورامالايونج ساركوما فى الأطفال بالمعهد القومى للأورام - مصر
260			_aCairo : _bAfaf Mohammad Mahmoud , _c2020
300			_a160 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aBackground: Survivin is an inhibitor of apoptosis protein that inhibits caspases and blocks cell death. It is undetectable in most normal adult tissues. High survivin expression has been detected in various tumors and has been correlated with therapy resistance and poor outcome. Objectives: We conducted this study to examine survivin expression in pediatric Ewing sarcoma family of tumors (ESFT), and evaluate its role in predicting clinical outcome. Patients and tnahods: Formalin-fixed paraffin-embedded tumor tissues from 108 pediatric patients with ESFT were examined for survivin status and percent of expression by immunostaining with survivin rabbit monoclonal antibodies. The relationship between survivin status and dinico-pathologic characteristics mod survival rates was evaluated. Results: Survival expression was detected in tumor tissues of 72 (66.7 %) patients. High expression (0.50%) was detected in only 18 (16.7%) patients.From all clinico-pathologic factors, positive survivin status was only strongly associated with male gender (p value= 0.041). In the Can proportional regression model analysis, high survivin expression was shown to be a significant univariate parameter for poorer overall (OS) and event free survival (EFS) with p value 0.033, and 0.037 respectively. Also, on multivariate analysis; it was an independent factor that significantly affect the OS (fi 0.041; BR 1.97 with 95% CI of 1.03-3.79), and EFS (p: 0.049; IIR 1.86 with 95% CI of 1.00-346). Conclusion: High expression of survivin in ESFT identifies a group of patients with poor prognosis.This result needs to be confirmed in prospective studies including larger number of patients thus survivin expression may in future help to refute risk adapted treatment
530			_aIssued also as CD
653		4	_aEwing Sarcoma
653		4	_aPediatric
653		4	_aSurvivin
700	0		_aEman Naguib Khorshed , _eSupervisor
700	0		_aLobna Mohamed Shalaby , _eSupervisor
700	0		_aWael Zekri Khaled , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c77571 _d77571