000			02289cam a2200349 a 4500
003			EG-GiCUC
005			20250223032602.0
008			200922s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.05.Ph.D.2020.Mo.D
100	0		_aMohamed Adel Sayed Mahmoud
245	1	0	_aDesign and synthesis of certain novel benzenesulfonamide derivatives with anticancer activity / _cMohamed Adel Sayed Mahmoud ; Supervised Sahar M. Abouseri , Dalia H. Soliman , Samar H. Fahim
246	1	5	_aتصميم و تشييد مجموعة من مشتقات البينزين سلفوناميد الجديدة ذات نشاط مضاد للسرطان
260			_aCairo : _bMohamed Adel Sayed Mahmoud , _c2020
300			_a182 P. : _bcharts , facsmilies ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry
520			_aCancer is one of the leading causes of death across the world, causing great stress to human life. Chemotherapy emerged to be important key player in the treatment of many of cancer patients ranging from primary to advanced stages. However, the severe side effects, poor tolerance and the development of resistance to chemotherapeutic drugs limited their use in many patients. Therefore, the development of novel, efficient, and less toxic anticancer agents remains a serious and challenging goal for the medicinal scientists worldwide. One of the most powerful discovered anticancer scaffolds is the benzenesulfonamide moiety attached to triazole or pyrazole rings. Therefore, the present study deals with the synthesis of different series of benzenesulfonamides hybridized with triazoles, fused triazoles and fused pyrazoles either through direct connection or via azo (-N=N-) spacer furnishing
530			_aIssued also as CD
653		4	_aAnticancer
653		4	_aBenzenesulfonamide derivatives
653		4	_aCancer
700	0		_aDalia H. Soliman , _eSupervisor
700	0		_aSahar M. Abouseri , _eSupervisor
700	0		_aSamar H. Fahim , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c77869 _d77869