| 000 | 02744cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032603.0 | ||
| 008 | 200924s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2020.Sa.E | ||
| 100 | 0 | _aSalah Abdullah Ahmed Abdo | |
| 245 | 1 | 0 |
_aEffect of antidepressants on experimentally induced colitis in normal and ovariectomized depressed rats / _cSalah Abdullah Ahmed Abdo ; Supervised Mahmoud Khattab , Rania Mohsen Abdelsalam , Walaa Wadie |
| 246 | 1 | 5 | _aتأثير مضادات الاكتئاب فى التهاب القولون الناجم تجريبيا على الجرذان الطبيعية و المكتبئة بسبب استئصال المبيض |
| 260 |
_aCairo : _bSalah Abdullah Ahmed Abdo , _c2020 |
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| 300 |
_a184 P. : _bcharts , facsmilies ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aEscitalopram, a drug of first-choice in the treatment of depression, was recently shown to possess an anti-inflammatory activity. The aim of the present study was to elucidate the effect of escitalopram on peripheral inflammatory cascades in iodoacetamide-induced colitis in normal and ovariectomized rats. Moreover, the involvement of Ü-7 nicotinic acetylcholine receptor in mediating the anti-colitic effect of escitalopram was examined using a nicotinic receptor antagonist methyllycaconitine citrate. Colitis was induced by intracolonic instillation of iodoacetamide. Escitalopram (10 mg/kg) was given once daily for one week. Treatment with escitalopram improved colitis as indicated by a decrease in weight loss, colon mass index, ulcerative area and total histology score. Moreover, it reversed iodoacetamide-induced rise in colonic myeloperoxidase activity, tumor necrosis factor-{uF061} level and corticotropin releasing hormone content. Escitalopram was also effective in normalizing the expression of tight junction proteins in colonic tissues. These potential effects of escitalopram were noticed in the presence of methyllycaconitine. The present study revealed the potential anti- inflammatory effect of escitalopram against iodoacetamide-induced colitis in normal and ovariectomized rats | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aColitis | |
| 653 | 4 | _aDepression | |
| 653 | 4 | _aEscitalopram | |
| 700 | 0 |
_aMahmoud Khattab , _eSupervisor |
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| 700 | 0 |
_aRania Mohsen Abdelsalam , _eSupervisor |
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| 700 | 0 |
_aWalaa Wadie , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAmira _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c77915 _d77915 |
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