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| 005 | 20250223032615.0 | ||
| 008 | 201018s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.03.M.Sc.2020.Ah.M | ||
| 100 | 0 | _aAhmed Mohamed Bahaa Eldin Khedr | |
| 245 | 1 | 0 |
_aMiRNA-22 and its relation to serum level of vitamin D and vitamin D receptor in patients with multiple sclerosis / _cAhmed Mohamed Bahaa Eldin Khedr ; Supervised Olfat Gamil Shaker , Amr Hassan , Taha Abdelrazik Azouz |
| 246 | 1 | 5 | _aميكرو إن إيه -22 وعلاقته بمستوى كلاً من فيتامين (د) ومستقبلات فيتامين (د) في مصل الدم في مرضى التصلب المتعدد |
| 260 |
_aCairo : _bAhmed Mohamed Bahaa Eldin Khedr , _c2020 |
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| 300 |
_a139 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry | ||
| 520 | _aBackground and aims: Micro-RNAs (MiRNAs) were believed to play a role in the pathogenesis of many neurological disorders. We investigated the expression of miRNA-22, vitamin D and vitamin D receptor levels in patients with multiple sclerosis (MS) to clarify their role in MS pathogenesis and their impact on clinical course of the disease (progression and disability). Methods: This case-control study was conducted on 100 subjects; 50 patients with MS fulfilling the 2010 McDonald's criteria and 50 healthy ages and sex matched control. The clinical disability was evaluated using the expanded disability status scale (EDSS). MiRNA-22 expression was performed using Quantitative RT-PCR. Serum level of vitamin D and vitamin D receptor were performed using ELISA techniques. Results: Our results demonstrated that the miRNA-22 was significantly downregulated in MS patients with p-value 0.001. The serum expression of Vit D and VDR were significantly downregulated in MS patients with p-value 0.001. Conclusion: This study suggests the possible role of low serum Vit D as well as serum expression of both miRNA-22 and VDR in MS pathogenesis. Suggesting a possible role of Vit D supplementation in treatment of MS. Further studies are required to clarify the molecular pathways through which miRNA-22 may influence MS pathogenesis and clinical presentation | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aMiRNA-22 | |
| 653 | 4 | _aMultiple sclerosis | |
| 653 | 4 | _aVitamin D | |
| 700 | 0 |
_aAmr Hassan , _eSupervisor |
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| 700 | 0 |
_aOlfat Gamil Shaker , _eSupervisor |
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| 700 | 0 |
_aTaha Abdelrazik Azouz , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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_c78283 _d78283 |
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