| 000 | 02752cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032615.0 | ||
| 008 | 201019s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.28.Ph.D.2020.Di.E | ||
| 100 | 0 | _aDina Mohamed Rashed Abdelhalim | |
| 245 | 1 | 0 |
_aEvaluation of serum Tumor Necrosis Factor alpha (TNFÜ) in type 1 diabetic children and adolescents as a predictor of diabetic Nnephropathy / _cDina Mohamed Rashed Abdelhalim ; Supervised Mona Attia Mahmoud Hana , Sahar Abdelatty Sharaf , Hend Mehawed Abdelatif |
| 246 | 1 | 5 | _aتقييم معامل نخر الأورام ألفا فى الدم الأطفال والمراهقين المصابين بالسكر من النوع الأول كمؤشر على إعتلال الكلية السكرى |
| 260 |
_aCairo : _bDina Mohamed Rashed Abdelhalim , _c2020 |
||
| 300 |
_a118 P . : _bcharts , facsmilies ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aIntroduction Type one diabetes mellitus (T1DM) incidence and prevalence showed a progressive increase over a period of 18 years among children aged from 0 to 18 years living in the Nile Delta region. Higher T1DM may lead to many complications, either acute or chronic.Chronic complications include nephropathy, retinopathy, neuropathy, stroke and cardiovascular diseases. Using a specific assay for albumin is a more sensitive technique. Recently, attention has been called to atypical presentations of diabetic nephropathy with dissociation of proteinuria from reduced kidney function .As a pleiotropic cytokine, tumor necrosis factor alpha (TNF-Ü ) exerts multiple effects and it can contribute to the development of diabetic nephropathy through several mechanisms, including reduction of the glomerular blood flow and glomerular filtration rate, vasoconstriction induced by increased endothelin-1 production, and disruption of the glomerular filtration barrier which is mediated by the interaction with the intercellular junctions and leads to proteinuria . The aim of our study is to evaluate the serum level of TNF-Ü as an early detector of diabetic nephropathy in children and adolescents with type T1DM | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aMicroalbuminuria | |
| 653 | 4 | _aSerum TNF-Ü | |
| 653 | 4 | _aType 1 diabetes mellitus | |
| 700 | 0 |
_aHend Mehawed Abdelatif , _eSupervisor |
|
| 700 | 0 |
_aMona Attia Mahmoud Hana , _eSupervisor |
|
| 700 | 0 |
_aSahar Abdelatty Sharaf , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAmira _eCataloger |
||
| 905 |
_aNazla _eRevisor |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c78296 _d78296 |
||