000			03095cam a2200349 a 4500
003			EG-GiCUC
005			20250223032616.0
008			201019s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.19.Ph.D.2020.Em.M
100	0		_aEman Mohammed Mohammed Hamed Haggag
245	1	0	_aMannose binding lectin gene polymorphism versus microbial virulence in the pathogenesis of vulvovaginal candidiasis / _cEman Mohammed Mohammed Hamed Haggag ; Supervised Iman Ezzat Wali , Alaa Mohammed Reda Awad , Mohammed Abdelaziz Elsharkawy
246	1	5	_aتعدد شكل جين سكر المانوز المرتبط بالليكتين مقابل فوعية الميكروبات في تولد مرض داء المبيضات الفرجى المهبلى
260			_aCairo : _bEman Mohammed Mohammed Hamed Haggag , _c2020
300			_a156 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology
520			_aVulvovaginal candidiasis (VVC) remains one of the most common infections of the female genital tract affecting millions of women every year. The current study was designed to determine the frequency of MBL2 gene polymorphism among Egyptian females with vulvovaginal candidiasis and to assess the role of Candida virulence attributes together with host genetic polymorphism in the pathogenesis of such a condition. The study population included 50 cases with vulvovaginal candidiasisand another 50 controls. Vaginal swabs were cultured and species identification was done. MBL2polymorphism in both cases and controls was determined by double amplification refractory mutation system (D-ARMs) from blood sample. Among the different risk factors that were compared between cases and controls, contraception and antifungal use were more in cases than controls, but only antifungals showed almost statistically significant difference between cases and controls (P value = 0.059).There was a statistically significant difference between C. albicans and non albicansCandida (NAC) esterase and phospholipase (P value <0.001).Thirty C. albicans isolates (81.1%) possessed three or more virulence factors, compared to only four NAC (30.8%) with statistically significant difference (P value = 0.002). As regards MBL2 polymorphism, the frequency of X allele was found to be significantly high in cases as compared to controls (P value {u2264} 0.001). B allele on codon 54 and L allele on promoter region were also more among cases than controls
530			_aIssued also as CD
653		4	_aCandida species
653		4	_aCandida virulence factors
653		4	_aMBL₂ polymorphisms Vulvovaginal Candidiasis
700	0		_aAlaa Mohammed Reda Awad , _eSupervisor
700	0		_aIman Ezzat Wali , _eSupervisor
700	0		_aMohammed Abdelaziz Elsharkawy , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c78331 _d78331