000			02864cam a2200313 a 4500
003			EG-GiCUC
008			201027s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2020.Al.F
100	0		_aAlaa Ibrahim Mohamed Ali
245	1	0	_aFormulation and evaluation of biodegradable carriers for an antispasmodic drug / _cAlaa Ibrahim Mohamed Ali ; Supervised Mohamed Aly Kassem , Khaled Fathy Elshaboury
246	1	5	_aصياغة و تقييم حوامل ذاتية التحلل لعقار مضاد للتقلصات
260			_aCairo : _bAlaa Ibrahim Mohamed Ali , _c2020
300			_a147 P. : _bcharts , facsmilies ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aOral dosage form is the most common and widely used route of administration, that{u2019}s mainly because; it is a simple, economical (solid oral dosage forms do not require sterile conditions),easy route of ingestion, flexible (suits several types of drug candidates), noninvasive (administration with pain avoidance), and most important it achieves both patient{u2019}s compliance and convenience. The large surface area of the gastrointestinal tract (300-400m2) is formed mainly of absorptive villi that is covered by enterocytes, goblet cells, and interspersed by follicle associated epithelium. The high transcytotic capacity of M cells covering these lymphoid regions (Peyer{u2019}s patches) increased their significance for drug delivery. Researchers are under constant pressure to find new methods for incorporating different technologies in oral dosage forms, even small enhancements in the technology of drug delivery can produce substantial enhancement in drug bioavailability and increase patient compliance. Now the majority of research projects are made to convert solid oral formulations into controlled dosage forms. The newly produced controlled release dosage forms are capable of achieving both sustained and controlled release. Polymers are the main component in producing controlled release dosage forms, due to their unique characteristics such as swellability, bioerosion and biodegradation in body fluids. The main purpose of controlled release dosage forms is to maintain the drug concentration in the body.Treatments of chronic diseases are the most potential drug candidates to be formulated as controlled release dosage forms
530			_aIssued also as CD
653		4	_aANOVA (analysis of variance)
653		4	_aAntispasmodic drug
653		4	_aBiodegradable carriers
700	0		_aKhaled Fathy Elshaboury , _eSupervisor
700	0		_aMohamed Aly Kassem , _eSupervisor
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c78468 _d78468